PMID: 22300367

Kusuhara H, Furuie H, Inano A, Sunagawa A, Yamada S, Wu C, Fukizawa S, Morimoto N, Ieiri I, Morishita M, Sumita K, Mayahara H, Fujita T, Maeda K, Sugiyama Y
Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.
Br J Pharmacol. 2012 Jul;166(6):1793-803. doi: 10.1111/j.1476-5381.2012.01887.x., [PubMed]
Sentences
No. Mutations Sentence Comment
20 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 22300367:20:115
status: NEW
view ABCG2 p.Gln141Lys details
 Pharmacogenetic studies, which focused on the non-synonymous single nucleotide polymorphism (SNP) of BCRP (421C>A, Q141K) associated with lower protein expression of BCRP (Kondo et al., 2004; Kobayashi et al., 2005), have disclosed the importance of BCRP in limiting oral bioavailability of drugs in human small intestine. Login to comment