ABCMdb

PMID: 22123129

Kurose K, Sugiyama E, Saito Y
Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in the clinical trials for novel drug development.
Drug Metab Pharmacokinet. 2012;27(1):9-54. Epub 2011 Nov 29., [PubMed]

Sentences

No. Mutations Sentence Comment

170 ABCG2 p.Gln141Lys ABCG2 p.Gln141Lys Frequencies of ABCG2 421ChA in different ethnic populations Country ¤Population¥ Allele frequencya Number of subjectsb Reference421ChA, Q141K Transporter activity Decreased Asia Eastern 0.301 1,602 Japan 0.313 411 0.350 10 322¥ 0.355 100 323¥ 0.266 124 324¥ 0.319 177 325¥ Korea 0.284 670 0.278 250 326¥ 0.280 275 327¥ 0.300 145 328¥ China 0.315 521 0.291 191 327¥ ¤Han¥ 0.342 95 329¥ ¤Han¥ 0.323 235 330¥ South-Eastern 0.295 237 Vietnam 0.311 140 327¥ Singapore ¤Chinese¥c 0.277 94 191¥ ¤Malay¥ 0.273 97 191¥ ¤Indian¥c 0.154 94 191¥ Europe 0.103 1,611 Northern Sweden 0.100 60 331¥ Western 0.107 1,314 Netherlandsd 0.120 100 332¥ Germany 0.100 349 333¥ 0.108 865 334¥ Southern Italy ¤Tuscany¥ 0.062 88 HapMape Eastern Hungary 0.094 149 335¥ Caucasians 0.105 479 Continued on next page: Continued: Country ¤Population¥ Allele frequencya Number of subjectsb Reference421ChA, Q141K Transporter activity Decreased European-Caucasians 0.107 84 329¥ Caucasians 0.087 150 336¥ 0.142 88 322¥ European-Americans 0.080 69 337¥ Caucasian-Americans 0.119 88 329¥ Africans 0.027 1,094 Africans ¤sub-Saharan¥ 0.009 938 329¥ African-Americans 0.053 94 329¥ 0.000 24 322¥ 0.039 38 337¥ The base A in the initiation codon ATG is denoted ¦1. a The total allele frequency in each population/region is calculated by dividing the sum of the each allele number by the total allele number in the population/region. b The subtotal number in each population/region is simply the sum of the subject numbers. c Excluded from total data in the South-Eastern Asia region. d The population included 1 African, 1 Asian and 5 mixed ethnic subjects ¤i.e., Caucasians were 93%¥. Login to comment