ABCMdb

PMID: 22090467

Guevara-Cruz M, Tovar AR, Aguilar-Salinas CA, Medina-Vera I, Gil-Zenteno L, Hernandez-Viveros I, Lopez-Romero P, Ordaz-Nava G, Canizales-Quinteros S, Guillen Pineda LE, Torres N
A dietary pattern including nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndrome.
J Nutr. 2012 Jan;142(1):64-9. Epub 2011 Nov 16., [PubMed]

Sentences

No. Mutations Sentence Comment

5 ABCA1 p.Arg230Cys Interestingly, participants in the DP group with MetS and the ABCA1 R230C variant had a greater decrease in BW and an increase in serum adiponectin concentration after 2 mo of dietary treatment than those with the ABCA1 R230R variant. Login to comment 36 ABCA1 p.Arg230Cys In Mexico, the polymorphisms of genes that are highly associated with BMI and T2D are ABCA1 (R230C), TCF7L2 (rs7903146), PPARG (rs1801282), and IRS1 (rs1801278) (18-21). Login to comment 37 ABCA1 p.Arg230Cys In Mexico, the polymorphisms of genes that are highly associated with BMI and T2D are ABCA1 (R230C), TCF7L2 (rs7903146), PPARG (rs1801282), and IRS1 (rs1801278) (1821). Login to comment 93 ABCA1 p.Arg219Lys ABCA1 p.Arg230Cys Single nucleotide polymorphisms of the ABCA1 R230C (rs9282541), ABCA1 R219K (rs2230806), TCF7L2 (rs7903146), PPARG (rs1801282), and IRS1 (rs1801278) genes were determined using PCR-based TaqMan allele discrimination assays (ABI Prism 7900 HT Sequence Detection System, Applied Biosystems) (30). Login to comment 95 ABCA1 p.Arg219Lys ABCA1 p.Arg230Cys Single nucleotide polymorphisms of the ABCA1 R230C (rs9282541), ABCA1 R219K (rs2230806), TCF7L2 (rs7903146), PPARG (rs1801282), and IRS1 (rs1801278) genes were determined using PCR-based TaqMan allele discrimination assays (ABI Prism 7900 HT Sequence Detection System, Applied Biosystems) (30). Login to comment 100 ABCA1 p.Arg230Cys The differences between the P and DP groups with respect to the ABCA1 R230C polymorphism were determined using multifactor ANOVA adjusted for BMI. When the main effects were identified by the initial analysis, post hoc analysis using Bonferroni correction was conducted. Login to comment 102 ABCA1 p.Arg230Cys The differences between the P and DP groups with respect to the ABCA1 R230C polymorphism were determined using multifactor ANOVA adjusted for BMI. When the main effects were identified by the initial analysis, post hoc analysis using Bonferroni correction was conducted. Login to comment 136 ABCA1 p.Arg219Lys ABCA1 p.Arg230Cys The number of participants with a specific genotype distribution (wild-type allele homozygote, variant heterozygote, variant homozygote) for each polymorphism was as follows: ABCA1 R230C (56, 11, 0,); ABCA1 R219K (37, 26, 4); TCF7L2 C/T (51,13,3); PPARG P12A (58 7,2,); and IRS1 G972R (59 7,1,). Login to comment 137 ABCA1 p.Arg219Lys ABCA1 p.Arg230Cys Allele frequencies (wild-type, variant) were as follows: ABCA1 R230C (91.8%, 8.2%); ABCA1 R219K (74.6%, 25.4%); TCF7L2 C/T (85.8%, 14.2%); PPARG P12A (91.8%, 8.2%); and IRS1 G972R (93.3%, 6.7%). Login to comment 138 ABCA1 p.Arg219Lys ABCA1 p.Arg230Cys ABCA1 p.Arg230Cys Associations between ABCA1 R230C and anthropometric and biochemical variables. Login to comment 139 ABCA1 p.Arg219Lys ABCA1 p.Arg230Cys ABCA1 p.Arg230Cys ABCA1 p.Arg230Cys The decrease in BW in the participants in the DP group with the ABCA1 R230C variant was significantly greater (25.0 6 1.9 kg) than those with ABCA1 R230R variant (21.7 6 2 kg), and the increase in the serum adiponectin concentration in participants with the ABCA1 R230C variant (1.7 6 1.6 mg/L) was significantly greater than in those with the ABCA1 R230R variant (0.2 6 1.0 mg/L) after 2 mo. Login to comment 140 ABCA1 p.Arg230Cys Associations between ABCA1 R230C and anthropometric and biochemical variables. Login to comment 141 ABCA1 p.Arg230Cys ABCA1 p.Arg230Cys The decrease in BW in the participants in the DP group with the ABCA1 R230C variant was significantly greater (25.0 6 1.9 kg) than those with ABCA1 R230R variant (21.7 6 2 kg), and the increase in the serum adiponectin concentration in participants with the ABCA1 R230C variant (1.7 6 1.6 mg/L) was significantly greater than in those with the ABCA1 R230R variant (0.2 6 1.0 mg/L) after 2 mo. Login to comment 142 ABCA1 p.Arg219Lys ABCA1 p.Arg230Cys The ABCA1 R230C, ABCA1 R219K, TCF7L2 C/T, PPARG P12A, and IRS1 G972R polymorphisms were not related to the other clinical or biochemical variables or the dietary treatments (data not shown). Login to comment 144 ABCA1 p.Arg219Lys ABCA1 p.Arg230Cys The ABCA1 R230C, ABCA1 R219K, TCF7L2 C/T, PPARG P12A, and IRS1 G972R polymorphisms were not related to the other clinical or biochemical variables or the dietary treatments (data not shown). Login to comment 153 ABCA1 p.Arg230Cys ABCA1 p.Arg230Cys The ABCA1 R230C variant was chosen for this study, because carriers of the ABCA1 R230C variant, which is exclusive to Native American individuals, is associated with low HDL concentrations, obesity, and T2D in the Mexican population (45). Login to comment 154 ABCA1 p.Arg230Cys Previous studies have demonstrated that adults with the ABCA1 R230C polymorphism respond better to a cholesterol-lowering diet than those with the R230R genotype (46). Login to comment 155 ABCA1 p.Arg230Cys ABCA1 p.Arg230Cys The ABCA1 R230C variant was chosen for this study, because carriers of the ABCA1 R230C variant, which is exclusive to Native American individuals, is associated with low HDL concentrations, obesity, and T2D in the Mexican population (45). Login to comment 156 ABCA1 p.Arg230Cys Previous studies have demonstrated that adults with the ABCA1 R230C polymorphism respond better to a cholesterol-lowering diet than those with the R230R genotype (46). Login to comment 158 ABCA1 p.Arg230Cys Interestingly, in spite of the higher risk of developing obesity or diabetes by Mexican mestizos with the ABCA1 R230C polymorphism, the participants in this study with this polymorphism had a better response to the DP and showed additional beneficial effects such as a greater reduction in BW and a greater increase in serum adiponectin concentrations (Fig. 2) without differences in energy intake compared to the participants with the ABCA1 R230R genotype. Login to comment 160 ABCA1 p.Arg230Cys ABCA1 p.Arg230Cys Although these results are very encouraging, additional experiments must be conducted in a larger population of individuals with the ABCA1 R230C variant to confirm these effects. Login to comment 161 ABCA1 p.Arg230Cys A possible explanation for the improved response to the dietary treatment by the participants with the ABCA1 R230C polymorphism could be because the C230 allele may have been necessary for survival in times of food shortages, allowing the conservation of cholesterol inside the cell. Login to comment 162 ABCA1 p.Arg230Cys Although these results are very encouraging, additional experiments must be conducted in a larger population of individuals with the ABCA1 R230C variant to confirm these effects. Login to comment 163 ABCA1 p.Arg230Cys A possible explanation for the improved response to the dietary treatment by the participants with the ABCA1 R230C polymorphism could be because the C230 allele may have been necessary for survival in times of food shortages, allowing the conservation of cholesterol inside the cell. Login to comment 171 ABCA1 p.Arg219Lys Four additional polymorphisms, ABCA1 R219K, IRS-1 (Gly972Arg), PPARG (P12A), and TCF2L7, were examined in the current study because they are associated with decreased coronary heart disease, insulin resistance, weight loss, and diabetes; however, there was no relationship between the DP group, the presence of these polymorphisms, and the clinical and biochemical variables. Login to comment 173 ABCA1 p.Arg219Lys Four additional polymorphisms, ABCA1 R219K, IRS-1 (Gly972Arg), PPARG (P12A), and TCF2L7, were examined in the current study because they are associated with decreased coronary heart disease, insulin resistance, weight loss, and diabetes; however, there was no relationship between the DP group, the presence of these polymorphisms, and the clinical and biochemical variables. Login to comment 237 ABCA1 p.Arg230Cys Whole-grain ready-to-eat oat FIGURE 2 Changes in BW (A) and serum adiponectin (B) in participants with MetS who consumed the DP or P for 2 mo with ABCA1 R230R or ABCA1 R230C genotypes. Login to comment 238 ABCA1 p.Arg230Cys Whole-grain ready-to-eat oat FIGURE 2 Changes in BW (A) and serum adiponectin (B) in participants with MetS who consumed the DP or P for 2 mo with ABCA1 R230R or ABCA1 R230C genotypes. Login to comment 270 ABCA1 p.Arg230Cys Villarreal-Molina MT, Flores-Dorantes MT, Arellano-Campos O, Villalobos-Comparan M, Rodriguez-Cruz M, Miliar-Garcia A, Huer- tas-Vazquez A, Menjivar M, Romero-Hidalgo S, Wacher NH, et al. Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Login to comment 271 ABCA1 p.Arg230Cys Villarreal-Molina MT, Flores-Dorantes MT, Arellano-Campos O, Villalobos-Comparan M, Rodriguez-Cruz M, Miliar-Garcia A, Huertas-Vazquez A, Menjivar M, Romero-Hidalgo S, Wacher NH, et al. Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Login to comment