PMID: 22015057

Garcia-Donas J, Esteban E, Leandro-Garcia LJ, Castellano DE, del Alba AG, Climent MA, Arranz JA, Gallardo E, Puente J, Bellmunt J, Mellado B, Martinez E, Moreno F, Font A, Robledo M, Rodriguez-Antona C
Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study.
Lancet Oncol. 2011 Nov;12(12):1143-50. Epub 2011 Oct 17., [PubMed]
Sentences
No. Mutations Sentence Comment
57 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 22015057:57:936
status: NEW
view ABCG2 p.Gln141Lys details
 See Online for webappendix Single nucleotide polymorphism Variation Patients* Homozygous wild-type Heterozygous Homozygous variant Minor allele frequency VEGFR2 rs2305948 C>T V297I 95 78 15 2 0·100 VEGFR2 rs1870377T>A Q472H 95 53 34 8 0·263 VEGFR3 rs307826 A>G T494A 95 80 15 0 0·079 VEGFR3 rs448012 C>G H890Q 94 32 48 14 0·404 VEGFR3 rs307821 G>T R1324L 95 78 16 1 0·095 PDGFR-α rs35597368T>C S478P 95 77 16 2 0·105 VEGF-A rs2010963 G>C 5´-UTR 95 47 37 11 0·311 VEGF-A rs699947 A>C Promoter 95 27 47 21 0·468 VEGF-A rs1570360 G>A Promoter 95 45 41 9 0·311 IL8 rs1126647 A>T 3´-UTR 94 35 48 11 0·372 CYP3A4 rs2740574 A>G Promoter 94 89 5 0 0·027 CYP3A5 rs776746 G>A Splicing 94 82 12 0 0·064 ABCB1 rs1045642 C>T I1145I 94 27 51 16 0·441 ABCB1 rs1128503 C>T G412G 95 36 45 14 0·384 ABCB1 rs2032582 G>T A893S 92 38 39 15 0·375 ABCG2 rs2231142 C>A Q141K 95 85 10 0 0·053 UTR=untranslated region. Login to comment