PMID: 21991360

Bikadi Z, Hazai I, Malik D, Jemnitz K, Veres Z, Hari P, Ni Z, Loo TW, Clarke DM, Hazai E, Mao Q
Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein.
PLoS One. 2011;6(10):e25815. Epub 2011 Oct 4., [PubMed]
Sentences
No. Mutations Sentence Comment
227 ABCB1 p.Leu975Cys
X
ABCB1 p.Leu975Cys 21991360:227:67
status: NEW
view ABCB1 p.Leu975Cys details
ABCB1 p.Ile340Cys
X
ABCB1 p.Ile340Cys 21991360:227:51
status: NEW
view ABCB1 p.Ile340Cys details
ABCB1 p.Val982Cys
X
ABCB1 p.Val982Cys 21991360:227:105
status: NEW
view ABCB1 p.Val982Cys details
ABCB1 p.Val981Cys
X
ABCB1 p.Val981Cys 21991360:227:84
status: NEW
view ABCB1 p.Val981Cys details
 For example, activities of the human P-gp mutants, I340C (in TM6), L975C (in TM12), V981C (in TM12), and V982C (in TM12), were found to be highly protected from inhibition by MTS-rhodamine by pre-treatment with rhodamine B, indicating that these residues likely participate in rhodamine B binding to human P-gp [48]. Login to comment