ABCMdb

PMID: 21884024

Hua WJ, Hua WX, Fang HJ
The role of OATP1B1 and BCRP in pharmacokinetics and DDI of novel statins.
Cardiovasc Ther. 2012 Oct;30(5):e234-41. doi: 10.1111/j.1755-5922.2011.00290.x. Epub 2011 May 25., [PubMed]

Sentences

No. Mutations Sentence Comment

43 ABCG2 p.Gln141Lys ABCG2 p.Gln141Lys Of these, the nonsynonymous 421C>A SNP that results in a glycine to lysine (Q141K) amino acid change has been studied most extensively. The Q141K SNP has been linked to decreased plasma membrane expression of BCRP, decreased drug transport, or reduced ATPase activity [20]. Login to comment 44 ABCG2 p.Gln141Lys The study suggested that Q141K SNP has functional consequences in the resulting BCRP protein [21]. Login to comment 46 ABCG2 p.Gln141Lys Thus, the Q141K SNP may lead to higher drug toxicity in some patient populations [23]. Login to comment 73 ABCG2 p.Gln141Lys ABCG2 p.Gln141Lys Of these, the nonsynonymous 421C>A SNP that results in a glycine to lysine (Q141K) amino acid change has been studied most extensively. The Q141K SNP has been linked to decreased plasma membrane expression of ABCG2, decreased drug transport or reduced ATPase activity [20,38]. Login to comment