ABCMdb

PMID: 21865731

Al-Nakkash L, Batia L, Bhakta M, Peterson A, Hale N, Skinner R, Sears S, Jensen J
Stimulation of murine intestinal secretion by daily genistein injections: gender-dependent differences.
Cell Physiol Biochem. 2011;28(2):239-50. Epub 2011 Aug 16., [PubMed]

Sentences

No. Mutations Sentence Comment

239 ABCC7 p.Gly551Asp ABCC7 p.Gly970Arg ABCC7 p.Glu193Lys The idea of mutation specific correctors was verified by Caputo et al. [51] whose results suggested that felodipine and the phenyglycine PG-01, exerted a wider pharmacological effect (acting on CFTR mutations E193K, G970R and G551D) compared to the lesser potentiative sulfonamide SF-01. Login to comment 240 ABCC7 p.Gly551Asp More recently, the newest CFTR corrector, VX-770, has been described in vitro to increase CFTR channel open probability in recombinant cells expressing mutated CFTR ( F508 and G551D) and to increase chloride secretion in human CF bronchial epithelia [52]. Login to comment 241 ABCC7 p.Gly551Asp Even more promising, oral application of VX-770 has been shown to be associated with improvements in lung function in patients with at least one G551D-allele, in a study aimed to determine the safety and adverse event profile of the drug [53]. Login to comment