PMID: 21857725

Kudzi W, Adjei GO, Ofori-Adjei D, Dodoo AN
Pharmacogenetics in ghana: reviewing the evidence.
Ghana Med J. 2011 Jun;45(2):73-80., [PubMed]
Sentences
No. Mutations Sentence Comment
71 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 21857725:71:391
status: NEW
view ABCG2 p.Gln141Lys details
 Table 2: Allele frequencies of Phase II genes in Ghanaian population Gene Allele No Variant Reference Phase II enzymes COMT 1947A 195 0.06 40 TPMT *3C *3C *8 719G 217 116 863 0.148 0.025 0.034 0.065 41 42 16 UGT1A1 -3156A 853 0.34 16 NAT2 *6 *14 850 800 0.27 0.10 16 16 GSTP1 I105V 837 0.50 16 Transporters ABCB1 3435T 3435T 3435T 3435T 194 206 172 861 0.11 0.17 0.17 0.12 36 43 44 16 ABCG2 Q141K 919 0.01 16 SDR5A2 129 0.19 38 Others TYMS 1494del 799 0.44 16 TNFα -238A 850 0.02 16 SGK1 I6C E8T 112 0.317 0.045 45 Two other phase 1 enzymes, CYP2A6 and CYP2B6, have been associated with efavirenz plasma concentration in HIV-infected patients. Login to comment