ABCMdb

PMID: 21643759

Li Y, Tang K, Zhou K, Wei Z, Zeng Z, He L, Wan C
Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease.
Mol Biol Rep. 2012 Feb;39(2):1809-13. Epub 2011 Jun 4., [PubMed]

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0 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease Yang Li • Kefu Tang • Kejun Zhou • Zhiyun Wei • Zhen Zeng • Lin He • Chunling Wan Received: 19 November 2010 / Accepted: 21 May 2011 / Published online: 4 June 2011 Ó Springer Science+Business Media B.V. 2011 Abstract In the past decade, a number of case-control studies have been conducted to investigate the relationship between the ATP-binding cassette transporter A1 (ABCA1) R219K polymorphism and coronary heart disease (CHD). Login to comment 13 ABCA1 p.Arg219Lys In conclusion, our results indicate that the ABCA1 R219K polymorphism is a protective factor of CHD in Asians, but not in Caucasians. Login to comment 27 ABCA1 p.Arg219Lys To date, many case-control studies have been carried out to investigate the relationship between ABCA1 R219K polymorphism and the risk of developing CHD, but the results were conflicting or inconclusive. Login to comment 29 ABCA1 p.Arg219Lys In an attempt to clarify this inconsistency, we combined data from relevant published population-based association studies to quantify the overall genetic effect of the ABCA1 R219K polymorphism on the risk of CHD. Login to comment 33 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys Inclusion criteria For inclusion, studies had to meet all of the following criteria: (1) be a case-control or cohort study published in a peer-reviewed journal; (2) examine the associations between CHD and ABCA1 R219K polymorphisms; (3) have determined the ABCA1 R219K polymorphisms in both cases and controls; (4) be independent from other studies; and (5) present original data on genotype distribution or obtain from the authors. Login to comment 51 ABCA1 p.Arg219Lys Meta-analysis results The meta-analysis of the R219K polymorphism included 20 studies with 9,437 cases and 16,270 controls. Login to comment 52 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys Meta-analysis results The meta-analysis of the R219K polymorphism included 20 studies with 9,437 cases and 16,270 controls. Login to comment 53 ABCA1 p.Arg219Lys Figure 1 shows the results of all studies of the R219K polymorphism and CHD. Login to comment 59 ABCA1 p.Arg219Lys Pooled OR is indicated by black diamonds Table 1 Summary estimates for the OR of ABCA1 R219K polymorphism in subgroup analyses Study population Studies, n OR (95% CI) P(Z)a P(Q)b I2 (%) P(Q)c All 20 0.80 (0.69-0.92) 0.001 \0.001 76 All in HWE 17 0.78 (0.66-0.92) 0.003 \0.001 79 Ethnicity 0.010 Caucasian 10 0.87 (0.73-1.04) 0.12 \0.001 77 Asian 8 0.69 (0.55-0.86) 0.0009 0.05 50 Other 2 0.70 (0.29-1.70) 0.43 Outcome 0.922 Coronary stenosis 12 0.78 (0.67-0.92) 0.002 0.03 49 Myocardial infarction 2 0.81 (0.67-0.98) 0.03 0.34 0 Combined 6 0.80 (0.59-1.08) 0.15 \0.001 90 Gender 0.381 Males 3 0.94 (0.80-1.09) 0.4 0.59 0 Femals 2 0.82 (0.41-1.63) 0.57 0.07 69 Combined 17 0.78 (0.66-0.92) 0.003 \0.001 78 HWE Hardy-Weinberg Equilibrium The OR was calculated using random effect model a Z test used to determine the significance of the overall OR b Cochran`s chi-square Q statistic test used to assess the heterogeneity in subgroups c Cochran`s chi-square Q statistic test used to assess the heterogeneity between subgroups Caucasians and the pooled OR was 0.87(95% CI 0.73-1.04; P(Z) = 0.12). Login to comment 60 ABCA1 p.Arg219Lys Pooled OR is indicated by black diamonds Table 1 Summary estimates for the OR of ABCA1 R219K polymorphism in subgroup analyses Study population Studies, n OR (95% CI) P(Z)a P(Q)b I2 (%) P(Q)c All 20 0.80 (0.69-0.92) 0.001 \0.001 76 All in HWE 17 0.78 (0.66-0.92) 0.003 \0.001 79 Ethnicity 0.010 Caucasian 10 0.87 (0.73-1.04) 0.12 \0.001 77 Asian 8 0.69 (0.55-0.86) 0.0009 0.05 50 Other 2 0.70 (0.29-1.70) 0.43 Outcome 0.922 Coronary stenosis 12 0.78 (0.67-0.92) 0.002 0.03 49 Myocardial infarction 2 0.81 (0.67-0.98) 0.03 0.34 0 Combined 6 0.80 (0.59-1.08) 0.15 \0.001 90 Gender 0.381 Males 3 0.94 (0.80-1.09) 0.4 0.59 0 Femals 2 0.82 (0.41-1.63) 0.57 0.07 69 Combined 17 0.78 (0.66-0.92) 0.003 \0.001 78 HWE Hardy-Weinberg Equilibrium The OR was calculated using random effect model a Z test used to determine the significance of the overall OR b Cochran`s chi-square Q statistic test used to assess the heterogeneity in subgroups c Cochran`s chi-square Q statistic test used to assess the heterogeneity between subgroups Caucasians and the pooled OR was 0.87(95% CI 0.73-1.04; P(Z) = 0.12). Login to comment 64 ABCA1 p.Arg219Lys Discussion This study represents the first application of meta-analysis to assess the risk for CHD in relation to the ABCA1 R219K polymorphism. Login to comment 65 ABCA1 p.Arg219Lys Discussion This study represents the first application of meta-analysis to assess the risk for CHD in relation to the ABCA1 R219K polymorphism. Login to comment 78 ABCA1 p.Arg219Lys One explanation about how ABCA1 R219K polymorphism modifies the risk of CHD is that ABCA1 may influence the plasma lipid levels. Login to comment 79 ABCA1 p.Arg219Lys One explanation about how ABCA1 R219K polymorphism modifies the risk of CHD is that ABCA1 may influence the plasma lipid levels. Login to comment 81 ABCA1 p.Arg219Lys Only the R219K was significantly associated with HDL-C concentration and CAD risk [29]. Login to comment 82 ABCA1 p.Arg219Lys Only the R219K was significantly associated with HDL-C concentration and CAD risk [29]. Login to comment 85 ABCA1 p.Arg219Lys It is probable that the protective function of R219K polymorphism is not only explained by increased plasma HDL-C level. Login to comment 86 ABCA1 p.Arg219Lys It is probable that the protective function of R219K polymorphism is not only explained by increased plasma HDL-C level. Login to comment 90 ABCA1 p.Arg219Lys Another probable mechanism is that R219K polymorphism induces the activity of ABCA1 protein, which mediates cholesterol efflux from peripheral cells back to liver independent of plasma HDL-C levels. Login to comment 91 ABCA1 p.Arg219Lys Another probable mechanism is that R219K polymorphism induces the activity of ABCA1 protein, which mediates cholesterol efflux from peripheral cells back to liver independent of plasma HDL-C levels. Login to comment 100 ABCA1 p.Arg219Lys reported that R219K variant appeared to be more protective for smokers and ex-smokers than non-smokers in the premature CHD group. Login to comment 101 ABCA1 p.Arg219Lys reported that R219K variant appeared to be more protective for smokers and ex-smokers than non-smokers in the premature CHD group. Login to comment 105 ABCA1 p.Arg219Lys Our meta-analysis supports an association of ABCA1 R219K polymorphism with CHD in Asians. Login to comment 106 ABCA1 p.Arg219Lys Our meta-analysis supports an association of ABCA1 R219K polymorphism with CHD in Asians. Login to comment 108 ABCA1 p.Arg219Lys In subgroup analyses, evidence was obtained to suggest different risk effects of R219K between populations of Caucasians and Asians. Login to comment 109 ABCA1 p.Arg219Lys In subgroup analyses, evidence was obtained to suggest different risk effects of R219K between populations of Caucasians and Asians. Login to comment