PMID: 21590773

Budde T, Haney J, Bien S, Schwebe M, Riad A, Tschope C, Staudt A, Jedlitschky G, Felix SB, Kroemer HK, Grube M
Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression.
J Pharm Sci. 2011 Sep;100(9):3951-8. doi: 10.1002/jps.22622. Epub 2011 May 17., [PubMed]
Sentences
No. Mutations Sentence Comment
125 ABCC1 p.Gly671Val
X
ABCC1 p.Gly671Val 21590773:125:654
status: NEW
view ABCC1 p.Gly671Val details
 OCTN1 for doxorubicin transport, but data on their role for cardiac uptake are missing.29,30 In contrast, efflux transporters of the ABC transporter family have already been shown to affect pharmacokinetics of their substrates and are present and functionally active in the heart.31,32 Among them MRP1 and P-gp are capable to transport doxorubicin, thereby possibly affecting cardiac drug concentrations.9,10 Therefore, it was not surprising that cardiac MRP1 expression and function have been associated with doxorubicin-induced cardiomyopathy.18,33 These findings were underlined by a human study indicating an association between a MRP1 polymorphism (Gly671Val) and acute anthracycline-induced cardiotoxicity.34 In contrast to MRP1, the effect of doxorubicin on cardiac P-gp expression has not been investigated so far. Login to comment