PMID: 21480930

Takeuchi Y, Fujino Y, Fukushima K, Watanabe M, Nakagawa T, Ohno K, Sasaki N, Sugano S, Tsujimoto H
Biological effect of tyrosine kinase inhibitors on three canine mast cell tumor cell lines with various KIT statuses.
J Vet Pharmacol Ther. 2011 Apr 12. doi: 10.1111/j.1365-2885.2011.01296.x., 2011-04-12 [PubMed]
Sentences
No. Mutations Sentence Comment
60 ABCB1 p.Asn508Ile
X
ABCB1 p.Asn508Ile 21480930:60:405
status: NEW
view ABCB1 p.Asn508Ile details
 These data are cited from our previous study (Takeuchi et al., 2010) Cell lines KIT mutation* Amino acid change Mutated exon Mutated domain HRMC - - - - CMMC1 Variant A 763-765 Del CAG 255 Del Gln Exon 5 Extracellular Variant B 1243 (A fi G) Lys415 Glu Exon 8 Extracellular ITD1718-1771 ITD573-590 Exon 11 Juxtamembrane Variant C 1521-1522 Ins T Nonsense mutation Exon 9 Extracellular VIMC1 1523 (A fi T) Asn508 Ile Exon 9 Extracellular ITD, internal tandem duplication. Login to comment 163 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 21480930:163:54
status: NEW
view ABCG2 p.Arg482Thr details
 Rh123 is extruded by another ABC transporter, such as Arg482 Thr mutant ABCG2 (Honjo et al., 2001). Login to comment