ABCMdb

PMID: 21455600

Siwiak M, Edelman A, Zielenkiewicz P
Structural models of CFTR-AMPK and CFTR-PKA interactions: R-domain flexibility is a key factor in CFTR regulation.
J Mol Model. 2011 Apr 1., 2011-04-01 [PubMed]

Sentences

No. Mutations Sentence Comment

121 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala However, experiments [7] have shown an 80% decrease in AMPK phosphorylation for the CFTR double mutant S737A-S768A. Login to comment 155 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala This shows that, at the molecular level, it is possible that 20% of the currently unexplained phosphorylation signal observed in the CFTR double mutant S737A-S768A incubated with AMPK may come from "activator" serines such as S813. Login to comment 156 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala This shows that, at the molecular level, it is possible that 20% of the currently unexplained phosphorylation signal observed in the CFTR double mutant S737A-S768A incubated with AMPK may come from "activator" serines such as S813. Login to comment