PMID: 21311410

Yamakawa Y, Hamada A, Nakashima R, Yuki M, Hirayama C, Kawaguchi T, Saito H
Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia.
Ther Drug Monit. 2011 Apr;33(2):244-50., [PubMed]
Sentences
No. Mutations Sentence Comment
77 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 21311410:77:435
status: VERIFIED
view ABCG2 p.Gln141Lys details
ABCB1 p.Trp212*
X
ABCB1 p.Trp212* 21311410:77:564
status: NEW
view ABCB1 p.Trp212* details
 Individual Clearance of Imatinib as a Function of Variant Genotypes Allele Region Effect* Number of Patients Allele Frequency† WT Het Var p q SLC22A11022C.T Exon6 P341L 24 8 2 0.82 0.18 SLCO1B1521T.C Exon6 V174A 26 7 1 0.87 0.13 SLCO1B3334T.G Exon3 S112A 5 10 19 0.29 0.71 ABCB11236C.T Exon12 G412G 5 19 10 0.43 0.57 ABCB12677G.T/A Exon21 A893S/T 10 14 10 0.50 0.50 ABCB13435C.T Exon26 I1145I 7 21 6 0.51 0.49 ABCG2421C.A Exon5 Q141K 21 13 0 0.81 0.19 CYP2C9430C.T Exon3 R144C 34 0 0 1.00 0.00 CYP2C91075A.C Exon7 I359L 33 1 0 0.99 0.01 CYP2C19636G.A Exon5 W212X 27 7 0 0.90 0.10 CYP2C19681G.A Exon4 Splice defect 16 13 5 0.66 0.34 CYP2D6100C.T Exon1 P34S 13 16 5 0.62 0.38 CYP2D61846G.A Exon4 Splice defect 34 0 0 1.00 0.00 CYP3A56986A.G Intron3 Splice defect 2 12 20 0.24 0.76 Allele Clearance 6 SD (L/hr) P WT Het Var WT vs Het vs Var WT + Het vs Var WT vs Het + Var SLC22A11022C.T 8.8 6 2.9 8.2 6 3.5 8.3 6 3.5 0.973 0.913 0.926 SLCO1B1521T.C 8.7 6 3.1 8.3 6 2.0 5.5 0.304 0.235 0.288 SLCO1B3334T.G 5.7 6 2.3 7.4 6 2.4 9.5 6 3.1 0.046 0.019 0.071 ABCB11236C.T 11.7 6 3.1 8.1 6 2.7 8.2 6 3.2 0.277 0.642 0.196 ABCB12677G.T/A 9.8 6 3.2 8.1 6 2.5 8.0 6 3.3 0.494 0.445 0.270 ABCB13435C.T 12.7 6 3.0 7.9 6 2.4 9.2 6 3.5 0.058 0.581 0.035 ABCG2421C.A 7.9 6 3.1 9.5 6 2.8 N/A 0.446 N/A 0.462 CYP2C9430C.T 8.3 6 3.0 N/A N/A N/A N/A N/A CYP2C91075A.C 8.6 6 3.0 10.0 N/A 0.508 N/A 0.647 CYP2C19636G.A 8.1 6 2.8 9.7 6 3.3 N/A 0.242 N/A 0.257 CYP2C19681G.A 8.6 6 3.6 9.5 6 2.6 7.0 6 1.1 0.473 0.252 0.852 CYP2D6100C.T 7.3 6 3.2 8.2 6 2.4 12.7 6 3.3 0.190 0.089 0.276 CYP2D61846G.A 8.3 6 3.0 N/A N/A N/A N/A N/A CYP3A56986A.G 6.3 6 1.0 7.9 6 3.4 9.4 6 2.8 0.285 0.323 0.175 *Number represents amino acid codon. Login to comment