PMID: 21262849

Shen H, Lee FY, Gan J
Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2).
J Pharmacol Exp Ther. 2011 May;337(2):423-32. Epub 2011 Jan 24., [PubMed]
Sentences
No. Mutations Sentence Comment
37 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 21262849:37:88
status: VERIFIED
view ABCG2 p.Gln141Lys details
 A significant association between survival beyond 15 months and the ABCG2 421CϾA (Q141K) polymorphism was observed in a clinical trial (p ϭ 0.05) of 64 patients with hormone-refractory prostate cancer randomized to receive docetaxel plus vinorelbine or docetaxel plus estramustine phosphate. Login to comment