PMID: 21247457

Cao XL, Yin RX, Wu DF, Miao L, Aung LH, Hu XJ, Li Q, Yan TT, Lin WX, Pan SL
Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations.
Lipids Health Dis. 2011 Jan 19;10:14., [PubMed]
Sentences
No. Mutations Sentence Comment
0 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:0:40
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RESEARCH Open Access Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations Xiao-Li Cao1,2 , Rui-Xing Yin1* , Dong-Feng Wu1 , Lin Miao1 , Lynn Htet Htet Aung1 , Xi-Jiang Hu1 , Qing Li1 , Ting-Ting Yan1 , Wei-Xiong Lin3 , Shang-Ling Pan4 Abstract Background: Several genetic variants in the ATP-binding cassette transporter A1 (ABCA1) gene have associated with modifications of serum high-density lipoprotein cholesterol (HDL-C) levels and the susceptibility for coronary heart disease, but the findings are still controversial in diverse racial/ethnic groups. Login to comment
2 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:2:71
status: NEW
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The present study was undertaken to detect the possible association of V825I (rs2066715) polymorphism in the ABCA1 gene and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Login to comment
4 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:4:148
status: NEW
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Polymerase chain reaction and restriction fragment length polymorphism assay combined with gel electrophoresis were performed for the genotyping of V825I variant, and then confirmed by direct sequencing. Login to comment
13 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:13:48
status: NEW
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Conclusion: The present study suggests that the V825I polymorphism in the ABCA1 gene is associated with male serum HDL-C and ApoAI levels in the Han, and serum TC levels in the Bai Ku Yao populations. Login to comment
14 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:14:37
status: NEW
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The difference in the association of V825I polymorphism and serum lipid levels between the two ethnic groups might partly result from different ABCA1 gene-enviromental interactions. Login to comment
31 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:31:20
status: NEW
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A common variant of V825I in the ABCA1 gene is a missense SNP in the exon 17 that locates in the middle part of the protein corresponding to sixth transmembrane a-helix with mutation of GTC&#ae;ATC. Login to comment
32 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:32:10
status: NEW
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ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:32:20
status: NEW
view ABCA1 p.Val825Ile details
A common variant of V825I in the ABCA1 gene is a missense SNP in the exon 17 that locates in the middle part of the protein corresponding to sixth transmembrane a-helix with mutation of GTC®ATC. Login to comment
33 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:33:10
status: NEW
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The ABCA1 V825I polymorphism has been found to be associated with modifications of serum HDL-C levels in some studies [26-29] but not in others [30-33]. Login to comment
40 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:40:73
status: NEW
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Therefore, the aim of the present study was to detect the association of V825I polymorphism in the ABCA1 gene and several environmental factors with serum lipid phenotypes in the Guangxi Bai Ku Yao and Han populations. Login to comment
41 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:41:73
status: NEW
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Therefore, the aim of the present study was to detect the association of V825I polymorphism in the ABCA1 gene and several environmental factors with serum lipid phenotypes in the Guangxi Bai Ku Yao and Han populations. Login to comment
106 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:106:89
status: NEW
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Genotypic and allelic frequencies Table 2 gives the genotypic and allelic frequencies of V825I polymorphism in the ABCA1 gene. Login to comment
107 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:107:89
status: NEW
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Genotypic and allelic frequencies Table 2 gives the genotypic and allelic frequencies of V825I polymorphism in the ABCA1 gene. Login to comment
110 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:110:27
status: NEW
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The nucleotide sequence of V825I polymorphism The results were shown as GG, GA and AA genotypes by PCR-RFLP, the GG, GA and AA genotypes were also confirmed by sequencing (Figure 3); respectively. Login to comment
111 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:111:27
status: NEW
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The nucleotide sequence of V825I polymorphism The results were shown as GG, GA and AA genotypes by PCR-RFLP, the GG, GA and AA genotypes were also confirmed by sequencing (Figure 3); respectively. Login to comment
118 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:118:23
status: NEW
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Figure 2 Genotyping of V825I polymorphism in the ABCA1 gene. Login to comment
119 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:119:23
status: NEW
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Figure 2 Genotyping of V825I polymorphism in the ABCA1 gene. Login to comment
131 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:131:55
status: NEW
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ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:131:737
status: NEW
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Table 2 Genotypic and allelic frequencies of the ABCA1 V825I polymorphism between the Bai Ku Yao and Han populations [n (%)] Group n Genotype Allele GG GA AA G A Bai Ku Yao 677 228 (33.7) 321 (47.4) 128 (18.9) 777 (57.4) 577 (42.6) Han Chinese 646 216 (33.4) 314 (48.6) 116 (18.0) 746 (57.7) 546 (42.3) c2 - 0.265 0.034 P - 0.876 0.854 Bai Ku Yao Male 324 110 (34.0) 153 (47.2) 61 (18.8) 373 (57.6) 275 (42.4) Female 353 118 (33.4) 168 (47.6) 67 (19.0) 404 (57.2) 302 (42.8) c2 - 0.210 0.016 P - 0.990 0.900 Han Chinese Male 315 104 (33.0) 154 (48.9) 57 (18.1) 362 (57.5) 268 (42.5) Female 331 112 (33.8) 160 (48.3) 59 (17.8) 384 (58.0) 278 (42.0) c2 - 0.490 0.030 P - 0.976 0.863 Figure 3 A part of the nucleotide sequence of the ABCA1 V825I polymorphism. Login to comment
132 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:132:55
status: NEW
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ABCA1 p.Val825Ile
X
ABCA1 p.Val825Ile 21247457:132:737
status: NEW
view ABCA1 p.Val825Ile details
Table 2 Genotypic and allelic frequencies of the ABCA1 V825I polymorphism between the Bai Ku Yao and Han populations [n (%)] Group n Genotype Allele GG GA AA G A Bai Ku Yao 677 228 (33.7) 321 (47.4) 128 (18.9) 777 (57.4) 577 (42.6) Han Chinese 646 216 (33.4) 314 (48.6) 116 (18.0) 746 (57.7) 546 (42.3) c2 - 0.265 0.034 P - 0.876 0.854 Bai Ku Yao Male 324 110 (34.0) 153 (47.2) 61 (18.8) 373 (57.6) 275 (42.4) Female 353 118 (33.4) 168 (47.6) 67 (19.0) 404 (57.2) 302 (42.8) c2 - 0.210 0.016 P - 0.990 0.900 Han Chinese Male 315 104 (33.0) 154 (48.9) 57 (18.1) 362 (57.5) 268 (42.5) Female 331 112 (33.8) 160 (48.3) 59 (17.8) 384 (58.0) 278 (42.0) c2 - 0.490 0.030 P - 0.976 0.863 Figure 3 A part of the nucleotide sequence of the ABCA1 V825I polymorphism. Login to comment
141 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:141:115
status: NEW
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These results indicate that the prevalence of the A allele variation of Table 3 Genotypic frequencies of the ABCA1 V825I polymorphism and serum lipid levels between the Bai Ku Yao and Han populations Genotype n TC (mmol/L) TG (mmol/L) HDL-C (mmol/L) LDL-C (mmol/L) ApoAI (g/L) ApoB (g/L) ApoAI/ApoB Bai Ku Yao GG 228 4.28 &#b1; 0.79 1.09 (0.80) 1.63 &#b1; 0.39 2.52 &#b1; 0.65 1.30 &#b1; 0.34 0.84 &#b1; 0.21 1.65 &#b1; 0.69 GA 321 4.26 &#b1; 0.82 0.96 (0.61) 1.64 &#b1; 0.41 2.52 &#b1; 0.68 1.28 &#b1; 0.29 0.83 &#b1; 0.22 1.64 &#b1; 0.63 AA 128 4.52 &#b1; 1.26 0.95 (0.61) 1.72 &#b1; 0.45 2.69 &#b1; 1.04 1.33 &#b1; 0.35 0.86 &#b1; 0.26 1.73 &#b1; 0.91 F - 3.839 4.621 2.073 2.358 1.460 0.663 0.862 P - 0.022 0.099 0.127 0.095 0.233 0.516 0.423 Male GG 110 4.29 &#b1; 0.80 1.25 (0.91) 1.65 &#b1; 045 2.43 &#b1; 0.68 1.36 &#b1; 0.39 0.82 &#b1; 0.21 1.81 &#b1; 0.86 GA 153 4.26 &#b1; 0.88 1.00 (0.66) 1.67 &#b1; 0.45 2.47 &#b1; 0.73 1.32 &#b1; 0.33 081 &#b1; 021 1.76 &#b1; 0.74 AA 61 4.53 &#b1; 1.62 1.02 (0.68) 1.74 &#b1; 0.56 2.63 &#b1; 1.33 1.40 &#b1; 0.44 0.83 &#b1; 0.30 1.96 &#b1; 1.19 F - 1.850 4.969 0.974 1.377 1.040 0.081 1.370 P - 0.159 0.083 0.379 0.254 0.355 0.922 0.256 Female GG 118 4.26 &#b1; 0.80 0.97(0.62) 1.60 &#b1; 0.33 2.59 &#b1; 0.62 1.25 &#b1; 0.26 0.87 &#b1; 0.20 1.50 &#b1; 0.44 GA 168 4.26 &#b1; 0.77 0.94(0.56) 1.62 &#b1; 0.36 2.57 &#b1; 0.63 1.24 &#b1; 0.25 0.85 &#b1; 0.22 1.53 &#b1; 0.47 AA 67 4.50 &#b1; 0.80 0.92(0.49) 1.69 &#b1; 0.31 2.73 &#b1; 0.68 1.27 &#b1; 0.22 0.89 &#b1; 0.20 1.51 &#b1; 0.45 F - 2.860 0.595 1.530 2.080 0.474 1.150 0.578 P - 0.059 0.743 0.220 0.126 0.623 0.320 0.560 Han Chinese GG 216 4.77 &#b1; 0.99 1.00 (0.57) 1.92 &#b1; 0.51 2.61 &#b1; 0.72 1.43 &#b1; 0.27 0.89 &#b1; 0.22 1.70 &#b1; 0.58 GA 314 4.71 &#b1; 1.06 1.01 (0.68) 1.90 &#b1; 0.48 2.62 &#b1; 0.81 1.42 &#b1; 0.28 0.89 &#b1; 0.24 1.69 &#b1; 0.57 AA 116 4.63 &#b1; 0.90 1.02 (0.70) 1.78 &#b1; 0.48 2.64 &#b1; 0.67 1.36 &#b1; 0.27 0.90 &#b1; 0.21 1.58 &#b1; 0.51 F - 0.600 0.682 3.797 0.190 3.650 0.220 1.930 P - 0.540 0.711 0.023 0.674 0.027 0.800 0.145 Male GG 104 4.77 &#b1; 1.03 1.01 (0.59) 1.89 &#b1; 0.55 2.62 &#b1; 0.73 1.42 &#b1; 0.30 0.90 &#b1; 0.23 1.69 &#b1; 0.68 GA 154 4.59 &#b1; 1.13 1.01 (0.64) 1.80 &#b1; 0.49 2.56 &#b1; 0.86 1.36 &#b1; 0.29 0.87 &#b1; 0.25 1.68 &#b1; 0.61 AA 57 4.50 &#b1; 1.04 1.03 (0.78) 1.71 &#b1; 0.49 2.58 &#b1; 0.72 1.32 &#b1; 0.30 0.88 &#b1; 0.22 1.61 &#b1; 0.59 F - 1.039 0.062 3.590 0.037 3.020 0.102 0.575 P - 0.355 0.970 0.029 0.964 0.049 0.903 0.564 Female GG 112 4.72 &#b1; 0.96 0.96 (0.56) 1.94 &#b1; 0.47 2.59 &#b1; 0.71 1.43 &#b1; 0.24 0.89 &#b1; 0.21 1.70 &#b1; 0.48 GA 160 4.83 &#b1; 0.97 1.02 (0.77) 1.99 &#b1; 0.45 2.68 &#b1; 0.75 1.43 &#b1; 0.26 0.91 &#b1; 0.22 1.72 &#b1; 0.53 AA 59 4.76 &#b1; 0.75 0.99(0.58) 1.85 &#b1; 0.47 2.70 &#b1; 0.63 1.39 &#b1; 0.23 0.93 &#b1; 0.20 1.55 &#b1; 0.42 F - 0.390 1.182 2.150 0.538 2.640 0.760 2.133 P - 0.677 0.554 0.118 0.585 0.073 0.469 0.120 TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B; ApoAI/ApoB, the ratio of apolipoprotein AI to apolipoprotein B. Login to comment
142 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:142:115
status: NEW
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These results indicate that the prevalence of the A allele variation of Table 3 Genotypic frequencies of the ABCA1 V825I polymorphism and serum lipid levels between the Bai Ku Yao and Han populations Genotype n TC (mmol/L) TG (mmol/L) HDL-C (mmol/L) LDL-C (mmol/L) ApoAI (g/L) ApoB (g/L) ApoAI/ApoB Bai Ku Yao GG 228 4.28 ± 0.79 1.09 (0.80) 1.63 ± 0.39 2.52 ± 0.65 1.30 ± 0.34 0.84 ± 0.21 1.65 ± 0.69 GA 321 4.26 ± 0.82 0.96 (0.61) 1.64 ± 0.41 2.52 ± 0.68 1.28 ± 0.29 0.83 ± 0.22 1.64 ± 0.63 AA 128 4.52 ± 1.26 0.95 (0.61) 1.72 ± 0.45 2.69 ± 1.04 1.33 ± 0.35 0.86 ± 0.26 1.73 ± 0.91 F - 3.839 4.621 2.073 2.358 1.460 0.663 0.862 P - 0.022 0.099 0.127 0.095 0.233 0.516 0.423 Male GG 110 4.29 ± 0.80 1.25 (0.91) 1.65 ± 045 2.43 ± 0.68 1.36 ± 0.39 0.82 ± 0.21 1.81 ± 0.86 GA 153 4.26 ± 0.88 1.00 (0.66) 1.67 ± 0.45 2.47 ± 0.73 1.32 ± 0.33 081 ± 021 1.76 ± 0.74 AA 61 4.53 ± 1.62 1.02 (0.68) 1.74 ± 0.56 2.63 ± 1.33 1.40 ± 0.44 0.83 ± 0.30 1.96 ± 1.19 F - 1.850 4.969 0.974 1.377 1.040 0.081 1.370 P - 0.159 0.083 0.379 0.254 0.355 0.922 0.256 Female GG 118 4.26 ± 0.80 0.97(0.62) 1.60 ± 0.33 2.59 ± 0.62 1.25 ± 0.26 0.87 ± 0.20 1.50 ± 0.44 GA 168 4.26 ± 0.77 0.94(0.56) 1.62 ± 0.36 2.57 ± 0.63 1.24 ± 0.25 0.85 ± 0.22 1.53 ± 0.47 AA 67 4.50 ± 0.80 0.92(0.49) 1.69 ± 0.31 2.73 ± 0.68 1.27 ± 0.22 0.89 ± 0.20 1.51 ± 0.45 F - 2.860 0.595 1.530 2.080 0.474 1.150 0.578 P - 0.059 0.743 0.220 0.126 0.623 0.320 0.560 Han Chinese GG 216 4.77 ± 0.99 1.00 (0.57) 1.92 ± 0.51 2.61 ± 0.72 1.43 ± 0.27 0.89 ± 0.22 1.70 ± 0.58 GA 314 4.71 ± 1.06 1.01 (0.68) 1.90 ± 0.48 2.62 ± 0.81 1.42 ± 0.28 0.89 ± 0.24 1.69 ± 0.57 AA 116 4.63 ± 0.90 1.02 (0.70) 1.78 ± 0.48 2.64 ± 0.67 1.36 ± 0.27 0.90 ± 0.21 1.58 ± 0.51 F - 0.600 0.682 3.797 0.190 3.650 0.220 1.930 P - 0.540 0.711 0.023 0.674 0.027 0.800 0.145 Male GG 104 4.77 ± 1.03 1.01 (0.59) 1.89 ± 0.55 2.62 ± 0.73 1.42 ± 0.30 0.90 ± 0.23 1.69 ± 0.68 GA 154 4.59 ± 1.13 1.01 (0.64) 1.80 ± 0.49 2.56 ± 0.86 1.36 ± 0.29 0.87 ± 0.25 1.68 ± 0.61 AA 57 4.50 ± 1.04 1.03 (0.78) 1.71 ± 0.49 2.58 ± 0.72 1.32 ± 0.30 0.88 ± 0.22 1.61 ± 0.59 F - 1.039 0.062 3.590 0.037 3.020 0.102 0.575 P - 0.355 0.970 0.029 0.964 0.049 0.903 0.564 Female GG 112 4.72 ± 0.96 0.96 (0.56) 1.94 ± 0.47 2.59 ± 0.71 1.43 ± 0.24 0.89 ± 0.21 1.70 ± 0.48 GA 160 4.83 ± 0.97 1.02 (0.77) 1.99 ± 0.45 2.68 ± 0.75 1.43 ± 0.26 0.91 ± 0.22 1.72 ± 0.53 AA 59 4.76 ± 0.75 0.99(0.58) 1.85 ± 0.47 2.70 ± 0.63 1.39 ± 0.23 0.93 ± 0.20 1.55 ± 0.42 F - 0.390 1.182 2.150 0.538 2.640 0.760 2.133 P - 0.677 0.554 0.118 0.585 0.073 0.469 0.120 TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B; ApoAI/ApoB, the ratio of apolipoprotein AI to apolipoprotein B. Login to comment
144 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:144:2070
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Table 4 Correlative factors for serum lipid parameters between the Bai Ku Yao and Han populations Lipid parameter Relative factor Standardized coefficient Standard error t P Bai plus Han TC Body mass index 0.100 0.150 2.318 0.021 Age 0.194 0.002 7.234 0.000 Ethnic group -1.159 0.050 -6.200 0.001 Diastolic blood pressure 0.094 0.003 3.400 0.001 Weight 0.164 0.006 0.164 0.000 Sex 0.087 0.061 0.087 0.005 TG Weight 0.216 0.004 7.889 0.000 Alcohol consumption 0.114 0.042 4.168 0.000 HDL-C Age 0.211 0.001 8.214 0.000 Ethnic group -0.235 0.023 -9.336 0.000 Alcohol consumption 0.233 0.018 8.246 0.000 Sex 0.127 0.026 4.541 0.000 Body mass index -0.069 0.004 -2.689 0.007 LDL-C Body mass index 0.093 0.012 2.097 0.036 Age 0.188 0.001 6.975 0.000 Alcohol consumption -0.090 0.029 -3.092 0.002 Weight 0.209 0.004 4.412 0.000 Sex 0.084 0.051 2.491 0.013 ApoAI Age 0.221 0.001 8.308 0.000 Alcohol consumption 0.230 0.012 8.126 0.000 Ethnic group -0.171 0.015 -6.759 0.000 Diastolic blood pressure 0.061 0.001 2.272 0.023 Sex 0.057 0.017 2.021 0.044 ApoB Body mass index 0.237 0.002 8.922 0.000 Age 0.160 0.000 5.999 0.000 Ethnic group -0.087 0.012 -3.393 0.001 Diastolic blood pressure 0.105 0.001 3.784 0.000 Sex 0.081 0.012 3.098 0.002 ApoAI/ApoB Alcohol consumption 0.165 0.023 6.103 0.000 Body mass index -0.155 0.006 -5.722 0.000 Bai Ku Yao TC Body mass index 0.216 0.014 5.821 0.000 Age 0.139 0.002 3.730 0.000 Genotype 0.076 0.048 2.051 0.041 TG Alcohol consumption 0.197 0.068 4.194 0.000 Body mass index 0.133 0.016 3.505 0.000 Sex -0.154 0.099 -3.099 0.002 Smoking -0.125 0.066 -2.485 0.013 HDL-C Alcohol consumption 0.204 0.022 5.502 0.000 Age 0.177 0.001 4.765 0.000 LDL-C Body mass index 0.219 0.012 5.812 0.000 Age 0.114 0.002 3.034 0.003 Alcohol consumption -0.080 0.042 -2.107 0.035 ApoAI Alcohol consumption 0.310 0.017 8.602 0.000 Age 0.167 0.001 4.639 0.000 ApoB Alcohol consumption 0.287 0.039 7.748 0.000 Body mass index -0.153 0.011 -4.138 0.000 ApoAI/ApoB Body mass index 0.207 0.004 5.463 0.000 Age 0.102 0.001 2.674 0.008 Sex 0.106 0.017 2.800 0.005 V825I in the ABCA1 gene may have an ethnic specificity. Login to comment
145 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:145:2070
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Table 4 Correlative factors for serum lipid parameters between the Bai Ku Yao and Han populations Lipid parameter Relative factor Standardized coefficient Standard error t P Bai plus Han TC Body mass index 0.100 0.150 2.318 0.021 Age 0.194 0.002 7.234 0.000 Ethnic group -1.159 0.050 -6.200 0.001 Diastolic blood pressure 0.094 0.003 3.400 0.001 Weight 0.164 0.006 0.164 0.000 Sex 0.087 0.061 0.087 0.005 TG Weight 0.216 0.004 7.889 0.000 Alcohol consumption 0.114 0.042 4.168 0.000 HDL-C Age 0.211 0.001 8.214 0.000 Ethnic group -0.235 0.023 -9.336 0.000 Alcohol consumption 0.233 0.018 8.246 0.000 Sex 0.127 0.026 4.541 0.000 Body mass index -0.069 0.004 -2.689 0.007 LDL-C Body mass index 0.093 0.012 2.097 0.036 Age 0.188 0.001 6.975 0.000 Alcohol consumption -0.090 0.029 -3.092 0.002 Weight 0.209 0.004 4.412 0.000 Sex 0.084 0.051 2.491 0.013 ApoAI Age 0.221 0.001 8.308 0.000 Alcohol consumption 0.230 0.012 8.126 0.000 Ethnic group -0.171 0.015 -6.759 0.000 Diastolic blood pressure 0.061 0.001 2.272 0.023 Sex 0.057 0.017 2.021 0.044 ApoB Body mass index 0.237 0.002 8.922 0.000 Age 0.160 0.000 5.999 0.000 Ethnic group -0.087 0.012 -3.393 0.001 Diastolic blood pressure 0.105 0.001 3.784 0.000 Sex 0.081 0.012 3.098 0.002 ApoAI/ApoB Alcohol consumption 0.165 0.023 6.103 0.000 Body mass index -0.155 0.006 -5.722 0.000 Bai Ku Yao TC Body mass index 0.216 0.014 5.821 0.000 Age 0.139 0.002 3.730 0.000 Genotype 0.076 0.048 2.051 0.041 TG Alcohol consumption 0.197 0.068 4.194 0.000 Body mass index 0.133 0.016 3.505 0.000 Sex -0.154 0.099 -3.099 0.002 Smoking -0.125 0.066 -2.485 0.013 HDL-C Alcohol consumption 0.204 0.022 5.502 0.000 Age 0.177 0.001 4.765 0.000 LDL-C Body mass index 0.219 0.012 5.812 0.000 Age 0.114 0.002 3.034 0.003 Alcohol consumption -0.080 0.042 -2.107 0.035 ApoAI Alcohol consumption 0.310 0.017 8.602 0.000 Age 0.167 0.001 4.639 0.000 ApoB Alcohol consumption 0.287 0.039 7.748 0.000 Body mass index -0.153 0.011 -4.138 0.000 ApoAI/ApoB Body mass index 0.207 0.004 5.463 0.000 Age 0.102 0.001 2.674 0.008 Sex 0.106 0.017 2.800 0.005 V825I in the ABCA1 gene may have an ethnic specificity. Login to comment
146 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:146:52
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Conversely, several previous studies found that the V825I polymorphism in the ABCA1 gene was associated with increased serum HDL-C levels [26-29]. Login to comment
147 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:147:52
status: NEW
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Conversely, several previous studies found that the V825I polymorphism in the ABCA1 gene was associated with increased serum HDL-C levels [26-29]. Login to comment
148 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:148:65
status: NEW
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They thought that the lack of significant association in men for V825I was partly due to less-significant effects on HDL-C in men. Login to comment
149 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:149:65
status: NEW
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They thought that the lack of significant association in men for V825I was partly due to less-significant effects on HDL-C in men. Login to comment
152 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:152:30
status: NEW
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ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:152:159
status: NEW
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Li et al. [29] found that the V825I polymorphism may affect ApoAI levels in Han Chinese population, but the influence depended on the haplotype generated from V825I and R1587K. Login to comment
153 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:153:30
status: NEW
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ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:153:159
status: NEW
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Li et al. [29] found that the V825I polymorphism may affect ApoAI levels in Han Chinese population, but the influence depended on the haplotype generated from V825I and R1587K. Login to comment
154 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:154:41
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In the current study, the association of V825I polymorphism and serum ApoAI levels, to some extent at least, was in agreement with a previous study in Han Chinese [29], but the influence on decreased serum HDL-C level in Han Chinese was reverse to that from Danish general population and European ancestry population [26-29]. Login to comment
155 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:155:41
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ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:155:87
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In the current study, the association of V825I polymorphism and serum ApoAI levels, to some extent at least, was in agreement with a previous study in Han Chinese [29], but the influence on decreased serum HDL-C level in Han Chinese was reverse to that from Danish general population and European ancestry population [26-29]. Login to comment
156 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:156:87
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However, several previous reports failed to find a significant association between the V825I polymorphism in the ABCA1 gene and serum HDL-C levels [30-33]. Login to comment
157 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:157:187
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Tan et al. [31] reported that no obviously changes in serum lipid levels were observed in G or A allele carriers in Singapore CHD and CHD-free males (Chinese, Malays and Indian), but the V825I polymorphism clearly associated Table 4 Correlative factors for serum lipid parameters between the Bai Ku Yao and Han populations (Continued) Diastolic blood pressure 0.094 0.001 2.365 0.018 Han Chinese TC Age 0.254 0.002 6.807 0.000 Diastolic blood pressure 0.128 0.004 3.264 0.001 Weight 0.281 0.004 7.109 0.000 Sex 0.165 0.076 4.387 0.000 TG Weight 0.278 0.005 7.293 0.000 Alcohol consumption 0.078 0.060 2.033 0.043 HDL-C Age 0.260 0.001 7.014 0.000 Alcohol consumption 0.218 0.023 5.628 0.000 Sex 0.151 0.039 3.770 0.000 Weight -0.100 0.002 -2.606 0.009 Genotype -0.088 0.025 -2.444 0.015 LDL-C Age 0.249 0.002 6.620 0.000 Weight 0.196 0.005 3.524 0.000 Alcohol consumption -0.124 0.035 -3.299 0.001 ApoAI Age 0.307 0.001 8.091 0.000 Alcohol consumption 0.170 0.013 4.441 0.000 Sex 0.169 0.021 4.464 0.000 Diastolic blood pressure 0.085 0.001 2.231 0.026 Genotype -0.071 0.014 -1.988 0.047 ApoB Body mass index 0.261 0.003 6.957 0.000 Age 0.228 0.001 6.086 0.000 Diastolic blood pressure 0.106 0.001 2.732 0.006 ApoAI/ApoB Body mass index -0.167 0.007 -4.305 0.000 TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B. Login to comment
158 ABCA1 p.Val825Ile
X
ABCA1 p.Val825Ile 21247457:158:187
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Tan et al. [31] reported that no obviously changes in serum lipid levels were observed in G or A allele carriers in Singapore CHD and CHD-free males (Chinese, Malays and Indian), but the V825I polymorphism clearly associated Table 4 Correlative factors for serum lipid parameters between the Bai Ku Yao and Han populations (Continued) Diastolic blood pressure 0.094 0.001 2.365 0.018 Han Chinese TC Age 0.254 0.002 6.807 0.000 Diastolic blood pressure 0.128 0.004 3.264 0.001 Weight 0.281 0.004 7.109 0.000 Sex 0.165 0.076 4.387 0.000 TG Weight 0.278 0.005 7.293 0.000 Alcohol consumption 0.078 0.060 2.033 0.043 HDL-C Age 0.260 0.001 7.014 0.000 Alcohol consumption 0.218 0.023 5.628 0.000 Sex 0.151 0.039 3.770 0.000 Weight -0.100 0.002 -2.606 0.009 Genotype -0.088 0.025 -2.444 0.015 LDL-C Age 0.249 0.002 6.620 0.000 Weight 0.196 0.005 3.524 0.000 Alcohol consumption -0.124 0.035 -3.299 0.001 ApoAI Age 0.307 0.001 8.091 0.000 Alcohol consumption 0.170 0.013 4.441 0.000 Sex 0.169 0.021 4.464 0.000 Diastolic blood pressure 0.085 0.001 2.231 0.026 Genotype -0.071 0.014 -1.988 0.047 ApoB Body mass index 0.261 0.003 6.957 0.000 Age 0.228 0.001 6.086 0.000 Diastolic blood pressure 0.106 0.001 2.732 0.006 ApoAI/ApoB Body mass index -0.167 0.007 -4.305 0.000 TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B. Table 5 Correlative factors for serum lipid parameters between males and females in both ethnic groups Lipid parameter Relative factor Standardized coefficient Standard error t P Bai Ku Yao Male TC Body mass index 0.268 0.023 5.036 0.000 Age 0.130 0.007 2.434 0.015 TG Body mass index 0.216 0.031 3.973 0.000 HDL-C Alcohol consumption 0.229 0.037 5.033 0.000 Age 0.275 0.002 4.286 0.000 Body mass index -0.116 0.011 -0.201 0.028 LDL-C Body mass index 0.261 0.021 4.854 0.000 ApoAI Alcohol consumption 0.313 0.028 5.887 0.000 Age 0.187 0.001 3.519 0.000 ApoB Body mass index 0.293 0.006 5.496 0.000 ApoAI/ApoB Alcohol consumption 0.272 0.068 4.983 0.000 Body mass index -0.188 0.022 -3.449 0.001 Female TC Body mass index 0.170 0.016 3.253 0.001 Age 0.148 0.003 2.824 0.005 TG Alcohol consumption 0.205 0.080 3.919 0.000 LDL-C Body mass index 0.168 0.013 3.209 0.001 Age 0.162 0.002 3.012 0.002 ApoAI Age 0.159 0.001 2.300 0.003 Body mass index 0.160 0.001 2.030 0.022 ApoB Systolic blood pressure 0.328 0.008 3.067 0.002 Body mass index 0.202 0.003 3.321 0.001 Weight 0.025 0.117 2.053 0.041 ApoAI/ApoB Diastolic blood pressure -0.155 0.003 -2.937 0.004 Han Chinese Male TC Weight 0.334 0.006 6.638 0.000 Age 0.228 0.003 4.424 0.000 Alcohol consumption 0.152 0.065 2.932 0.004 TG Weight 0.385 0.009 7.379 0.000 HDL-C Age 0.336 0.002 6.729 0.000 Alcohol consumption 0.309 0.031 6.148 0.000 Weight -0.016 0.003 -3.278 0.007 Genotype -0.131 0.035 -2.711 0.000 LDL-C Weight 0.287 0.004 5.389 0.000 Age 0.174 0.007 3.273 0.001 ApoAI Age 0.377 0.001 7.609 0.000 Alcohol consumption 0.278 0.017 5.622 0.000 Genotype -0.125 0.020 -2.599 0.010 ApoB Body mass index 0.295 0.004 5.718 0.000 Age 0.208 0.001 3.930 0.000 Smoking 0.124 0.014 2.422 0.016 Alcohol consumption 0.106 0.015 2.005 0.046 ApoAI/ApoB Age 0.118 0.020 2.100 0.037 Body mass index -0.172 0.011 -3.054 0.002 Female TC Age 0.278 0.007 5.317 0.000 Weight 0.210 0.006 4.075 0.000 Diastolic blood pressure 0.152 0.005 2.855 0.005 with CHD status in male Malays. Login to comment
160 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:160:41
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To our knowledge, the association of the V825I polymorphism and serum TC levels has not been described previously. Login to comment
174 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:174:8
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But the V825I polymorphism in the ABCA1 gene is found to be associated with male serum HDL-C and ApoAI levels in the Han, and serum TC levels in the Bai Ku Yao populations. Login to comment
176 ABCA1 p.Val825Ile
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ABCA1 p.Val825Ile 21247457:176:37
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The difference in the association of V825I polymorphism and serum lipid levels between the two ethnic groups might partly result from different ABCA1 gene-enviromental interactions. Login to comment