PMID: 21182225

Zhao J, Yu BY, Wang DY, Yang JE
Promoter polymorphism of MRP1 associated with reduced survival in hepatocellular carcinoma.
World J Gastroenterol. 2010 Dec 28;16(48):6104-10., 2010-12-28 [PubMed]
Sentences
No. Mutations Sentence Comment
45 ABCC1 p.Arg723Gln
X
ABCC1 p.Arg723Gln 21182225:45:21
status: NEW
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 For example, G2168A (Arg723Gln) can affect patients` sensitivity to chemotherapy in ovarian cancer[11] . Login to comment 46 ABCC1 p.Arg1058Gln
X
ABCC1 p.Arg1058Gln 21182225:46:164
status: NEW
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ABCC1 p.Arg433Ser
X
ABCC1 p.Arg433Ser 21182225:46:8
status: NEW
view ABCC1 p.Arg433Ser details
 G1299T (Arg433Ser) confers resistance to doxorubicin by reducing intracellular drug accumulation in HeLa cells that stably express mutant MRP1, whereas the G3173A (Arg1058Gln) variation increases the response to etoposide in HEK293 and CHO-K1 cells[12,13] . Login to comment