PMID: 21106720

Yue W, Lee JK, Abe K, Sugiyama Y, Brouwer KL
Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR) rats.
Drug Metab Dispos. 2011 Mar;39(3):441-7. Epub 2010 Nov 24., [PubMed]
Sentences
No. Mutations Sentence Comment
15 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 21106720:15:49
status: VERIFIED
view ABCG2 p.Gln141Lys details
 A single nucleotide polymorphism in ABCG2 C421A (Q141K) has been associated with altered drug disposition in clinical studies (elevated plasma concentrations of diflomotecan after intravenous administration and of topotecan and rosuvastatin after oral administration) (Sparreboom et al., 2004, 2005; Zhang et al., 2006a). Login to comment