PMID: 20972558

Kim KA, Joo HJ, Park JY
Effect of ABCG2 genotypes on the pharmacokinetics of A771726, an active metabolite of prodrug leflunomide, and association of A771726 exposure with serum uric acid level.
Eur J Clin Pharmacol. 2011 Feb;67(2):129-34. Epub 2010 Oct 23., [PubMed]
Sentences
No. Mutations Sentence Comment
17 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 20972558:17:217
status: VERIFIED
view ABCG2 p.Gln141Lys details
ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 20972558:17:169
status: VERIFIED
view ABCG2 p.Val12Met details
 Several ABCG2 genetic variants have been reported; the most frequent ABCG2 polymorphisms detected among different ethnic groups are c.34G>A (rs2231137), which codes for V12M, and c.421C>A (rs2231142), which codes for Q141K [4]. Login to comment