ABCMdb

PMID: 20922799

Tanaka M, Okazaki T, Suzuki H, Abbruzzese JL, Li D
Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome.
Cancer. 2011 Feb 15;117(4):744-51. doi: 10.1002/cncr.25510. Epub 2010 Oct 4., 2011-02-15 [PubMed]

Sentences

No. Mutations Sentence Comment

75 ABCG2 p.Gln141Lys ABCC2 p.Val417Ile Minor Allele Frequency Observeda /Reportedb MDR1 7q21.12a Ex27 -55T>C I1145I 1045642 0.49/0.47 MRP1 16p13.11a Ex28 36G>A S1219S 2239330 0.28/0.24 MRP2 10q24.2c Ex10 40G>A V417I 2273697 0.25/0.23 Ex28 -16C>T I1324I 3740066 0.35/0.35 MRP3 17q21.33b Ex26 -13C>T H1314H 2277624 0.24/0.17 MRP4 13q32.1a Ex8 40A>G R317R 2274406 0.39/0.37 MRP5 3q27.1b Ex10 -2A>G Q382Q 7636910 0.35/0.39 BCRP 4q22.1b Ex5 43C>A Q141K 2231142 0.12/0.10 SNP indicates single-nucleotide polymorphism; RS No., reference SNP identification number. Login to comment 88 ABCG2 p.Cys43Ala Overall Survival by Genotype Genotype No. of Patients No. of Deaths MST6SE (Months) Log-Rank P HRa (95% CI) P MDR1 T-55C CC 45 32 23.8Æ5.3 CT 64 46 21.5Æ3.3 TT 43 31 21.7Æ3.4 .982 CC vs TT/CT .869 1.24 (0.81-1.90) .317 MRP1 G36A GG 81 64 21.5Æ2.4 AG 60 38 23.9Æ9.3 AA 13 9 21.4Æ6.1 .247 AA/AG vs GG .136 1.03 (0.69-1.53) .890 MRP2 G40A GG 86 67 21.2Æ2.6 AG 55 34 31.0Æ7.1 AA 10 7 17.5Æ4.8 .172 AG/AA vs GG .097 1.55 (1.02-2.36) .040 MRP2 C-16T CC 63 44 23.9Æ4.2 CT 69 49 20.7Æ4.0 TT 19 15 22.5Æ2.2 .962 CC vs TT/CT .785 1.13 (0.75-1.69) .557 MRP3 C-13T CC 89 67 21.4Æ2.3 CT 47 32 28.7Æ7.0 TT 13 8 23.9Æ10.9 .307 CT/TT vs CC .129 1.10 (0.72-1.67) .664 MRP4 A40G GG 54 34 26.4Æ8.1 AG 76 58 21.7Æ2.4 AA 22 17 14.6Æ2.6 .172 GG/AG vs AA .158 1.29 (0.75-2.23) .357 MRP5 A-2G AA 68 54 18.4Æ3.0 AG 62 38 31.0Æ4.2 GG 22 17 20.7Æ7.0 .017 AG/GG vs AA .010 1.65 (1.11-2.45) .013 BCRP C43A CC 116 83 23.9Æ3.3 AC 27 19 21.2Æ0.8 AA 4 3 20.4Æ10.0 .960 AA/AC vs CC .960 1.05 (0.65-1.72) .834 No. of deleterious allelesb .006 0 39 21 34.0Æ12.0 1-2 112 87 20.7Æ1.5 2.18 (1.32-3.60) .002 MST, median survival time; SE, standard error; HR, Hazard ratio a HR was adjusted for history of diabetes, tumor size, serum level of CA19-9, tumor response, and tumor resection. Login to comment 116 ABCG2 p.Cys43Ala Although MDR1 T-55C and BCRP C43A were reported to be functional SNPs that change their protein functions,25,29 none of these SNPs-nor the MRP1, MRP3, or MRP4 gene SNPs examined in this study-had any association with overall survival or tumor response to therapy. Login to comment