ABCMdb

PMID: 20720558

Takahashi N, Miura M, Scott SA, Kagaya H, Kameoka Y, Tagawa H, Saitoh H, Fujishima N, Yoshioka T, Hirokawa M, Sawada K
Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia.
J Hum Genet. 2010 Nov;55(11):731-7. Epub 2010 Aug 19., [PubMed]

Sentences

No. Mutations Sentence Comment

6 ABCG2 p.Gln141Lys Moreover, previous studies have shown that the ABCG2 421C4A (p.Q141K) variant is prevalent among Japanese and Han Chinese individuals and less common among Africans and Caucasians. Login to comment 24 ABCB1 p.Glu255Lys ABCB1 p.Glu255Val In patients without a CCyR, mutation analysis of the bcr-abl fusion transcript was performed using the Invader assay,31 which detects 25 mutations, including M244V, L248VR, G250E, Q252H, Q252R, Y253F, Y253H, E255K, E255V, E279K, F311L, T315A, T315I, F317L, M351T, F359IV, V379I, L387M, H396P, H396R, S417Y, E459K and F486S. Login to comment 79 ABCG2 p.Gln141Lys In addition, our study identified a significant correlation between ABCG2 421C4A (p.Q141K) and IM trough concentration, suggesting an important role for the BCRP efflux transporter in IM metabolism. Login to comment 231 ABCG2 p.Gln141Lys 44 Imai, Y., Nakane, M., Kage, K., Tsukahara, S., Ishikawa, E., Tsuruo, T. et al. C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Login to comment