ABCMdb

PMID: 20520284

Lee SH, Lee MS, Lee JH, Kim SW, Kang RH, Choi MJ, Park SJ, Kim SJ, Lee JM, Cole SP, Lee MG
MRP1 polymorphisms associated with citalopram response in patients with major depression.
J Clin Psychopharmacol. 2010 Apr;30(2):116-25., [PubMed]

Sentences

No. Mutations Sentence Comment

68 ABCC1 p.Arg723Gln Genotype and Allele Analysis of SNPs in Control and Patients SNP (rs#) Position Control vs Patients Remitted vs Nonremitted Genotype Genotype Allele CTL PT W2 P R NR W2 P R NR W2 P g.-1989A9G AA 17 18 3.13 0.209 10 8 0.03 0.986 A 36 29 0.03 0.872 (rs12929977) AG 56 29 16 13 (0.930) Promoter GG 25 17 9 8 G 34 29 g.-1841G9A GG 21 19 2.93 0.231 11 8 0.28 0.868 G 36 30 0.10 0.753 (rs4148330) GA 58 28 14 14 (0.624) Promoter AA 20 15 8 7 A 30 28 c.1062T9C(N354N) CC 27 20 1.83 0.400 11 9 1.94 0.378 C 40 29 0.65 0.420 (rs35587) CT 39 29 18 11 (0.973) Exon 9 TT 33 15 6 9 T 30 29 c.2168G9A(R723Q) GG 91 53 3.42 *0.142 30 23 1.72 *0.491 G 64 52 0.12 0.732 (rs4148356) GA 7 10 4 6 (0.499) Exon 17 AA 1 1 1 0 A 6 6 IVS18-30G9C GG 53 39 0.90 *0.676 22 17 0.40 *0.897 G 56 45 0.11 0.739 (rs2074087) GC 42 23 12 11 (0.729) Intron 18 CC 4 2 1 1 C 14 13 c.4002G9A(S1334S) GG 78 46 2.26 *0.328 21 25 6.01 *† 0.038 G 52 54 7.89 † 0.005 (rs2239330) GA 19 14 10 4 *† (0.026) Exon 28 AA 2 4 4 0 A 18 4 IVS28-45G9A GG 67 38 0.91 0.633 18 20 3.38 *0.194 G 46 48 3.77 0.052 (rs212087) GA 23 18 10 8 (0.195) Intron 28 AA 9 7 6 1 A 22 10 IVS29-13delT TT 38 21 0.42 0.810 15 6 3.53 0.171 T 44 28 2.73 0.099 (rs4148379) T/d 43 30 14 16 (0.060) Intron 29 d/d 17 11 5 6 d 24 28 c.5462T9A(3`UTR) TT 71 42 0.80 *0.671 20 22 4.14 *0.133 T 51 51 4.45 † 0.035 (rs212090) TA 22 18 11 7 (0.117) Exon 31 AA 7 4 4 0 A 19 7 *Fisher exact test was done; the P values were calculated using the codominant model. Login to comment