ABCMdb

PMID: 20504109

Choong E, Dobrinas M, Carrupt PA, Eap CB
The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution.
Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):953-65., [PubMed]

Sentences

No. Mutations Sentence Comment

209 ABCC1 p.Ala893Ser ABCB1 p.Asn183Ser ABCB1 p.Asn21Asp ABCB1 p.Ser1141Thr ABCB1 p.Arg492Cys Different SNPs were associated with the phenotype of remission, and carriers of the C allele for the rs2032583 genotype had higher odds ratio for remission (7.72, 95% CI 2.8 -- 21.3) at 4 weeks Exon 7 Exon 13 Exon 11Exon 2 Exon 8 Exon 6 Exon 3 Exon 4 Exon 9 Exon 17 Exon 10 Exon 14 Exon 12 Exon 15 Exon 16 Exon 19 Exon 21 Exon 18 Exon 23 Exon 24 Exon 28 Exon 27 Exon 20 Exon 22 A893S Exon 25 Exon 26 Exon 5 N21D N183S N400S Variant (548G, Ser183) MDR1*1 (548A, Asn183) Variant (2677T, Ser893) S1141T ATP-binding domain ATP-binding domain MDR1*1 (2677g, Ala893) R492C A. B. Figure 2. Login to comment