PMID: 20367534

Rodrigues AC
Efflux and uptake transporters as determinants of statin response.
Expert Opin Drug Metab Toxicol. 2010 May;6(5):621-32., [PubMed]
Sentences
No. Mutations Sentence Comment
98 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 20367534:98:55
status: NEW
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 The ACCESS study showed an association between G2677T (S893A) single nucleotide polymorphism (SNP) and changes on LDL and total cholesterol after atorvastatin treatment [41]. Login to comment 126 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 20367534:126:145
status: NEW
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 Reduced BCRP transport activity has been associated with the presence of the ABCG2 c.421C>A SNP (rs2231142), resulting in an amino acid change p.Gln141Lys [53-55]. Login to comment 138 ABCG8 p.Asp19His
X
ABCG8 p.Asp19His 20367534:138:87
status: NEW
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 And, recently, it was reported by Kajinami et al. that the variant allele of the ABCG8 D19H polymorphism was significantly associated with higher reductions in LDL cholesterol (-39.7 vs -36.2%) after atorvastatin therapy [60]. Login to comment