PMID: 20207952

Bailey KM, Romaine SP, Jackson BM, Farrin AJ, Efthymiou M, Barth JH, Copeland J, McCormack T, Whitehead A, Flather MD, Samani NJ, Nixon J, Hall AS, Balmforth AJ
Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study.
Circ Cardiovasc Genet. 2010 Jun;3(3):276-85. Epub 2010 Mar 5., [PubMed]
Sentences
No. Mutations Sentence Comment
28 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 20207952:28:149
status: VERIFIED
view ABCG2 p.Gln141Lys details
 In vitro pharmacokinetic evidence strongly suggests that common nonsynonymous SNPs in the SLCO1B1 (521TϾC; Val174 Ala) and BCRP (421CϾA; Gln141 Lys) genes both result in markedly decreased transport function and thus could potentially play a significant role in determining rosuvastatin concentration within the hepatocyte.23-29 It is a continual challenge to the medical profession to seek to match individual treatments to individual patients (personalized medicine). Login to comment