PMID: 20038957

Deeken JF, Cormier T, Price DK, Sissung TM, Steinberg SM, Tran K, Liewehr DJ, Dahut WL, Miao X, Figg WD
A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform.
Pharmacogenomics J. 2010 Jun;10(3):191-9. Epub 2009 Dec 29., [PubMed]
Sentences
No. Mutations Sentence Comment
125 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 20038957:125:495
status: NEW
view ABCG2 p.Gln141Lys details
 Human microsome studies did not find a significant role for CYP2D6 and other CYP enzymes in thalidomide metabolism.54 It is also possible that certain CYP2D6 alleles may confer a multiple-chemical sensitivity phenotype that increases the likelihood of development of toxicities after drug treatment in general.55 Table 5 Concordance between DMET and direct sequencing genotyping Gene SNP Concordance CYP17 A1A1 100 CYP2C19 *2 97 CYP2C19 *3 100 CYP1B1 *3 96 CYP3A5 *3C 100 ABCB1 2677G4T 96 ABCG2 Q141K 100 PPAR-d Rs2076167 100 Abbreviations: DMET, drug-metabolizing enzymes and transporters; SNP, single-nucleotide polymorphism. Login to comment