PMID: 20035425

Akasaka K, Kaburagi T, Yasuda S, Ohmori K, Abe K, Sagara H, Ueda Y, Nagao K, Imura J, Imai Y
Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancer.
Cancer Chemother Pharmacol. 2010 Sep;66(4):691-8. Epub 2009 Dec 25., [PubMed]
Sentences
No. Mutations Sentence Comment
2 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 20035425:2:39
status: NEW
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 Since c.421C [ A ABCG2, resulting in p.Q141K substitution, is more prevalent in Asian populations, the putative relationship between gefitinib-induced adverse effects and this functional polymorphism was investigated in Japanese patients. Login to comment 97 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 20035425:97:56
status: NEW
view ABCG2 p.Gln141Lys details
 In contrast, the c.421C [ A polymorphism results in a p.Q141K variant ABCG2, of which expression level is 3-to 5-fold lower than that of the wild type in spite of similar mRNA levels [22]. Login to comment