PMID: 19930591

Andersen V, Ostergaard M, Christensen J, Overvad K, Tjonneland A, Vogel U
Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.
BMC Cancer. 2009 Nov 21;9:407., [PubMed]
Sentences
No. Mutations Sentence Comment
36 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 19930591:36:53
status: VERIFIED
view ABCG2 p.Gln141Lys details
 The variant allele of the non-synonymous BCRP C421A (Q141K) polymorphism has been associated with lower protein levels and lowered transport activity both in vitro [34,35] and in vivo [27,35], but no associations were found between either the intestinal levels of protein and mRNA and BRCP polymorphisms [36] or between BCRP polymorphisms and risk of CRC [4]. Login to comment