ABCMdb

PMID: 19842935

Keskitalo JE, Pasanen MK, Neuvonen PJ, Niemi M
Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.
Pharmacogenomics. 2009 Oct;10(10):1617-24., [PubMed]

Sentences

No. Mutations Sentence Comment

9 ABCG2 p.Gln141Lys One of the most studied variations, c.421C>A (p.Gln141Lys; rs2231142), has been associated with reduced transport activity of ABCG2 in vitro [4-10]. Login to comment 17 ABCG2 p.Gln141Lys The participants Aims: This study aimed to investigate possible effects of the ABCG2 c.421C>A (p.Gln141Lys; rs2231142) genotype on fluvastatin, pravastatin and simvastatin pharmacokinetics. Login to comment 160 ABCG2 p.Gln141Lys 7 Imai Y, Nakane M, Kage K et al.: C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Login to comment 161 ABCG2 p.Gln141Lys 7 Imai Y, Nakane M, Kage K etal.: C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Login to comment