ABCMdb

PMID: 19835554

Franke RM, Gardner ER, Sparreboom A
Pharmacogenetics of drug transporters.
Curr Pharm Des. 2010;16(2):220-30., [PubMed]

Sentences

No. Mutations Sentence Comment

102 ABCG2 p.Gln141Lys In particular, a SNP in exon 5 of the ABCG2 gene has been described, in which a 421C>A transversion results in a lysine to glutamine amino acid change at codon 141 (Q141K) [68]. Login to comment 104 ABCG2 p.Val12Met ABCG2 p.Ile206Leu ABCG2 p.Asn590Tyr Several other SNPs have been identified in coding regions of the gene, and at least three additional non-synonymous SNPs have been identified occurring at positions 34 (V12M; exon 2), 616 (I206L, exon 6), and 1768 (N590Y, exon 15). Login to comment 108 ABCG2 p.Gln141Lys Specifically, recent studies have demonstrated that subjects with a reduced ABCG2 activity due to the Q141K variant are at an increased risk for gefitinib-induced diarrhea [72], and altered pharmacokinetics of 9-aminocamptothecin, diflomotecan, irinotecan, rosuvastatin, sulfasalazine, and topotecan [64]. Login to comment