PMID: 19766125

Moran O
Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators.
J Theor Biol. 2010 Jan 7;262(1):73-9. Epub 2009 Sep 17., [PubMed]
Sentences
No. Mutations Sentence Comment
57 ABCC7 p.Arg555Lys
X
ABCC7 p.Arg555Lys 19766125:57:61
status: NEW
view ABCC7 p.Arg555Lys details
ABCC7 p.Thr1246Asn
X
ABCC7 p.Thr1246Asn 19766125:57:71
status: NEW
view ABCC7 p.Thr1246Asn details
 Disruption of the binding site on NBD1 and NBD2 by mutations R555K and T1246N, respectively, yield an approximation of the independent equilibrium constants, KATP1 ¼ 71 mM and KATP2 ¼ 261 mM (Vergani et al., 2005). Login to comment 59 ABCC7 p.Arg555Lys
X
ABCC7 p.Arg555Lys 19766125:59:61
status: NEW
view ABCC7 p.Arg555Lys details
ABCC7 p.Thr1246Asn
X
ABCC7 p.Thr1246Asn 19766125:59:71
status: NEW
view ABCC7 p.Thr1246Asn details
 Disruption of the binding site on NBD1 and NBD2 by mutations R555K and T1246N, respectively, yield an approximation of the independent equilibrium constants, KATP1 &#bc; 71 mM and KATP2 &#bc; 261 mM (Vergani et al., 2005). Login to comment