ABCMdb

PMID: 19687781

Siedlinski M, Boezen HM, Boer JM, Smit HA, Postma DS
ABCC1 polymorphisms contribute to level and decline of lung function in two population-based cohorts.
Pharmacogenet Genomics. 2009 Sep;19(9):675-84., [PubMed]

Sentences

No. Mutations Sentence Comment

72 ABCC1 p.Gly671Val ABCC1 p.Arg433Ser Table 2 Additive effects of 53 ABCC1 SNPs on the level and change of FEV1 in the Doetinchem cohort (n = 1152) Additive effect on the level of FEV1 (ml)a Additive effect on the change of FEV1 (ml/year)b SNP Position MAF (%) HWE P value B SE P B SE P rs4148330 50 region 34.2 0.96 - 63.2 20.4 0.002 - 1.8 1.4 0.20 rs504348 [28] 50 region 19.3 0.61 - 54.9 24.7 0.03 - 2.4 1.7 0.15 rs152022 Intron 1 20.3 0.12 9.0 24.0 0.71 0.4 1.6 0.83 rs215049 Intron 1 31.9 0.72 - 32.5 21.1 0.12 - 1.5 1.5 0.31 rs215068 Intron 1 30.9 0.21 22.7 21.5 0.29 - 0.7 1.5 0.64 rs215079 Intron 1 21.0 0.24 3.2 23.9 0.89 - 1.5 1.7 0.37 rs215100 Intron 1 32.1 0.77 - 48.8 20.9 0.02 - 1.0 1.4 0.50 rs246220 Intron 1 12.6 0.34 - 19.0 30.1 0.53 1.2 2.1 0.55 rs4781699 Intron 1 31.4 0.63 - 56.6 20.9 0.01 - 2.2 1.4 0.13 rs8060750 Intron 1 12.7 0.52 24.4 29.2 0.40 - 1.1 2.0 0.59 rs8045000 Intron 1 32.8 - - 51.2 20.8 0.01 - 1.8 1.4 0.20 rs7190484 Intron 1 38.1 - - 48.8 20.1 0.02 - 1.8 1.4 0.19 rs7196970 Intron 1 40.6 - - 28.6 20.1 0.15 - 1.0 1.4 0.49 rs215101 Intron 1 10.5 - 36.2 33.1 0.27 - 0.9 2.2 0.70 rs4781711 Intron 1 6.9 - - 22.0 41.5 0.60 0.3 2.9 0.91 rs215059 Intron 1 14.2 - 15.6 28.8 0.59 0.8 2.0 0.69 rs4148337 Intron 3 31.9 0.72 - 25.4 21.0 0.23 - 1.0 1.4 0.51 rs4781718 Intron 3 14.3 0.39 - 0.1 27.8 0.99 - 2.1 1.9 0.28 rs246213 Intron 5 8.8 0.97 - 46.9 34.9 0.18 - 2.9 2.4 0.24 rs246240 Intron 5 18.0 0.28 3.1 25.3 0.90 - 0.7 1.7 0.71 rs7188937 Intron 5 46.4 - - 22.0 19.2 0.25 - 1.9 1.3 0.14 rs246233 Intron 6 9.0 - - 8.8 37.7 0.82 1.8 2.6 0.49 rs246230 Intron 7 14.6 0.42 - 5.2 27.5 0.85 - 0.1 1.9 0.97 rs193537 Intron 7 29.5 - - 14.0 22.3 0.53 - 0.2 1.5 0.89 rs60782127 (Arg433Ser) [29,30] Exon 10 2.2 1.00 - 25.2 68.0 0.71 3.3 4.7 0.48 rs12445600 Intron 10 27.8 0.57 - 22.8 22.0 0.30 - 0.5 1.5 0.74 rs4148344 Intron 10 15.7 - 12.5 28.4 0.66 0.5 1.9 0.80 rs35596 Intron 12 23.1 0.44 - 11.0 23.7 0.64 0.9 1.6 0.57 rs35597 Intron 12 46.7 0.33 32.9 20.1 0.10 3.1 1.4 0.02 rs35610 Intron 13 15.8 0.30 - 38.0 27.5 0.17 - 1.6 1.9 0.41 rs35621 Intron 14 10.7 0.61 -7.8 31.4 0.80 - 3.0 2.1 0.17 rs4148353 Intron 15 14.8 0.46 - 4.5 28.3 0.87 0.4 2.0 0.84 rs45511401 (Gly671Val) [30,31] Exon 16 4.9 1.00 22.5 45.4 0.62 - 0.7 3.1 0.81 rs2074086 Intron 18 31.9 0.43 11.7 21.0 0.58 - 1.0 1.4 0.49 rs2074087 Intron 18 14.2 - 42.1 30.6 0.17 - 3.6 2.1 0.08 rs4148358 Intron 19 23.5 0.94 11.1 23.2 0.63 - 0.1 1.6 0.93 rs2283515 Intron 19 46.6 - - 17.5 19.8 0.38 - 2.8 1.3 0.04 rs12449239 Intron 19 14.9 - - 20.4 29.8 0.49 - 0.7 2.0 0.74 rs11864374 Intron 21 22.6 0.62 - 27.4 24.2 0.26 - 2.9 1.6 0.08 rs9933511 Intron 21 27.1 0.09 9.5 22.7 0.68 - 0.5 1.5 0.75 rs3819552 Intron 21 49.0 0.57 6.6 19.9 0.74 2.7 1.4 0.04 rs2238475 Intron 23 4.6 0.16 - 10.8 46.0 0.82 1.2 3.2 0.71 rs2238476 Intron 23 5.9 0.74 28.0 41.5 0.50 - 1.5 2.8 0.59 rs12599429 Intron 26 31.8 0.85 17.7 21.5 0.41 2.0 1.5 0.17 rs212079 Intron 26 4.1 0.85 - 20.3 50.0 0.69 - 5.9 3.4 0.09 rs212083 Intron 27 19.5 0.46 - 10.6 24.6 0.67 - 3.9 1.7 0.02 rs2230671 (Ser1334Ser) Exon 28 29.8 0.98 5.7 21.6 0.79 1.9 1.5 0.19 rs3743527 30 UTR 22.5 0.09 - 58.6 23.5 0.01 - 1.3 1.6 0.44 rs212090 30 UTR 45.5 - - 11.2 19.4 0.56 4.3 1.3 0.001 rs212093 30 region 45.3 0.10 - 42.5 19.3 0.03 - 2.9 1.3 0.03 rs4148382 30 region 9.7 1.00 94.2 33.4 0.005 - 3.6 2.3 0.11 rs212094 30 region 18.0 - 15.9 25.8 0.54 - 5.3 1.8 0.003 rs12448760 30 region 29.1 - -7.5 21.6 0.73 2.7 1.5 0.07 The lack of HWE P values indicates haplotype-tagged SNPs. Login to comment