ABCMdb

PMID: 19625650

Luciani A, Villella VR, Vasaturo A, Giardino I, Raia V, Pettoello-Mantovani M, D'Apolito M, Guido S, Leal T, Quaratino S, Maiuri L
SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation.
J Immunol. 2009 Aug 15;183(4):2775-84. Epub 2009 Jul 22., 2009-08-15 [PubMed]

Sentences

No. Mutations Sentence Comment

52 ABCC7 p.Trp1282* Materials and Methods Cell lines and cultures Human CF bronchial epithelial cell line IB3-1, carrying F508del/W1282X CFTR mutation, isogenic stably rescued C38, normal bronchial epithelial 16HBE, or lung carcinoma A549 cell lines (LGC Standards) were cultured as recommended by American Type Culture Collection. Login to comment 53 ABCC7 p.Trp1282* Materials and Methods Cell lines and cultures Human CF bronchial epithelial cell line IB3-1, carrying F508del/W1282X CFTR mutation, isogenic stably rescued C38, normal bronchial epithelial 16HBE, or lung carcinoma A549 cell lines (LGC Standards) were cultured as recommended by American Type Culture Collection. Login to comment 77 ABCC7 p.Trp1282* ABCC7 p.Asn1303Lys ABCC7 p.Gly542* Patients and ex vivo cultures of nasal polyp mucosal biopsies Seven consecutive CF patients carrying the common CFTR mutations (F508del/F508del, F508del/W1282X, F508del/N1303K, or F508del/ G542X) (mean age, 19 years; range, 13-29 years) with chronic sinusitis and nasal polyposis and seven consecutive non-CF patients (mean age, 21 years; range, 16-32 years) with idiopathic polyposis underwent surgical treatment. Login to comment 78 ABCC7 p.Trp1282* ABCC7 p.Asn1303Lys ABCC7 p.Gly542* Patients and ex vivo cultures of nasal polyp mucosal biopsies Seven consecutive CF patients carrying the common CFTR mutations (F508del/F508del, F508del/W1282X, F508del/N1303K, or F508del/ G542X) (mean age, 19 years; range, 13-29 years) with chronic sinusitis and nasal polyposis and seven consecutive non-CF patients (mean age, 21 years; range, 16-32 years) with idiopathic polyposis underwent surgical treatment. Login to comment 135 ABCC7 p.Trp1282* Results PIASy-mediated TG2 SUMOylation increases TG2 protein levels in CF airway epithelial cells To investigate whether posttranslational modifications could result in the persistence of high levels of TG2 protein, we first analyzed IB3-1 CF epithelial cell lines carrying F508-del/W1282X CFTR mutations and the isogenic stably rescued C38 cells. Login to comment 136 ABCC7 p.Trp1282* Results PIASy-mediated TG2 SUMOylation increases TG2 protein levels in CF airway epithelial cells To investigate whether posttranslational modifications could result in the persistence of high levels of TG2 protein, we first analyzed IB3-1 CF epithelial cell lines carrying F508-del/W1282X CFTR mutations and the isogenic stably rescued C38 cells. Login to comment