ABCMdb

PMID: 19474787

Keskitalo JE, Zolk O, Fromm MF, Kurkinen KJ, Neuvonen PJ, Niemi M
ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.
Clin Pharmacol Ther. 2009 Aug;86(2):197-203. Epub 2009 May 27., [PubMed]

Sentences

No. Mutations Sentence Comment

18 ABCG2 p.Gln141Lys The c.421C>A SNP (rs2231142), resulting in an amino acid change p.Gln141Lys, is one of the best-characterized sequence variations in the ABCG2 gene. Login to comment 22 ABCG2 p.Gln141Lys this SNP affects ABCG2 function; some studies have suggested that it reduces ABCG2 expression,11,14-16 and other studies have suggested that it reduces the ATPase activity of ABCG2.12,17 However, the p.Gln141Lys variant is located within the cell apart from the ATP-binding region. Login to comment 186 ABCG2 p.Gln141Lys et al. C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low‑level drug resistance. Login to comment 187 ABCG2 p.Gln141Lys et al. C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low‑level drug resistance. Login to comment