PMID: 19387463

Ramos PS, Langefeld CD, Bera LA, Gaffney PM, Noble JA, Moser KL
Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC.
Genes Immun. 2009 Jun;10(4):350-5. Epub 2009 Apr 23., [PubMed]
Sentences
No. Mutations Sentence Comment
66 ABCB3 p.Val379Ile
X
ABCB3 p.Val379Ile 19387463:66:86
status: NEW
view ABCB3 p.Val379Ile details
ABCB3 p.Thr665Ala
X
ABCB3 p.Thr665Ala 19387463:66:128
status: NEW
view ABCB3 p.Thr665Ala details
 Past studies of TAP2 association with SLE have focused on three specific amino acids (V379I (rs1800454), A565 T (rs2228396) and T665A (rs241447)), had modest sample sizes (B100-200 cases) in ethnically diverse populations and were collectively inconclusive.7-11 Of these three SNPs, only rs241447 was included in our analyses, and it yielded a modest association. Login to comment