ABCMdb

PMID: 19328185

Hegedus T, Aleksandrov A, Mengos A, Cui L, Jensen TJ, Riordan JR
Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.
Biochim Biophys Acta. 2009 Jun;1788(6):1341-9. Epub 2009 Mar 26., [PubMed]

Sentences

No. Mutations Sentence Comment

131 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala ABCC7 p.Ser700Ala On the other hand, the much lower rate of S813 phosphorylation appeared to be reduced somewhat further by either the S700A or S737A substitutions, but not by the S768A substitution. Login to comment 132 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala ABCC7 p.Ser700Ala On the other hand, the much lower rate of S813 phosphorylation appeared to be reduced somewhat further by either the S700A or S737A substitutions, but not by the S768A substitution. Login to comment 151 ABCC7 p.Ser737Ala ABCC7 p.Ser813Ala ABCC7 p.Ser768Ala ABCC7 p.Ser700Ala Membranes isolated from BHK cells expressing S700A (A), S737A (B), S768A (C), or S813A (D) were subjected to phosphorylation for 0, 2, 4, 8, 16, 32, and 64 min. Login to comment 152 ABCC7 p.Ser737Ala ABCC7 p.Ser813Ala ABCC7 p.Ser768Ala ABCC7 p.Ser700Ala Membranes isolated from BHK cells expressing S700A (A), S737A (B), S768A (C), or S813A (D) were subjected to phosphorylation for 0, 2, 4, 8, 16, 32, and 64 min. Login to comment 241 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala The S737A and S768A constructs exhibit slightly higher basal open probability (Po =0.06) compared to wild type (Po âa;0.01) in good agreement with data of Csanady et al. [24]. Login to comment 242 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala The S737A and S768A constructs exhibit slightly higher basal open probability (Po =0.06) compared to wild type (Po ≪0.01) in good agreement with data of Csanady et al. [24]. Login to comment 244 ABCC7 p.Ser737Ala The channel properties of the S737A mutant were previously reported to be very similar to those of the wild type by Wilkinson et al. [10]. Login to comment 245 ABCC7 p.Ser737Ala The channel properties of the S737A mutant were previously reported to be very similar to those of the wild type by Wilkinson et al. [10]. Login to comment