PMID: 19135109

Robey RW, To KK, Polgar O, Dohse M, Fetsch P, Dean M, Bates SE
ABCG2: a perspective.
Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13. Epub 2008 Dec 16., 2009-01-31 [PubMed]
Sentences
No. Mutations Sentence Comment
1282 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 19135109:1282:109
status: VERIFIED
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 Of these, the nonsynonymous 421CNA single nucleotide polymorphism (SNP) that results in a glycine to lysine (Q141K) amino acid change has been studied most extensively. Login to comment 1283 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 19135109:1283:4
status: VERIFIED
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 The Q141K SNP has been linked to decreased plasma membrane expression of ABCG2, decreased drug transport or reduced ATPase activity [138-141]. Login to comment 1284 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 19135109:1284:39
status: VERIFIED
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 Some small studies have shown that the Q141K SNP alters the pharmacokinetics of chemotherapeutic agents such as topotecan, diflomotecan, and 9-aminocamptothecin [142-144]. Login to comment 1286 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 19135109:1286:10
status: VERIFIED
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 Thus, the Q141K SNP maylead to higher drug toxicity in some patient populations. Login to comment 1336 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 19135109:1336:4
status: VERIFIED
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 The Q141K SNP offers the possibility to do similar studies with ABCG2. Login to comment