PMID: 18851956

Rebecchi IM, Rodrigues AC, Arazi SS, Genvigir FD, Willrich MA, Hirata MH, Soares SA, Bertolami MC, Faludi AA, Bernik MM, Dorea EL, Dagli ML, Avanzo JL, Hirata RD
ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment.
Biochem Pharmacol. 2009 Jan 1;77(1):66-75. Epub 2008 Sep 21., 2009-01-01 [PubMed]
Sentences
No. Mutations Sentence Comment
26 ABCC1 p.Ala893Ser
X
ABCC1 p.Ala893Ser 18851956:26:115
status: NEW
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ABCC1 p.Ala893Thr
X
ABCC1 p.Ala893Thr 18851956:26:126
status: NEW
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ABCC1 p.Ala893Pro
X
ABCC1 p.Ala893Pro 18851956:26:141
status: NEW
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 The G2677T/A/C (rs2032582) is a non-synonymous polymorphism in the exon 21 with three distinct amino acid changes (Ala893Ser, Ala893Thr, and Ala893Pro, respectively) that is located at the transmembrane domain of the protein and it has a great impact on both the activity and the substrate specificity of ABCB1 toward different test compounds [10]. Login to comment 31 ABCC1 p.Gly671Val
X
ABCC1 p.Gly671Val 18851956:31:55
status: NEW
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 The ABCC1 G2012T (rs45511401) is a non-synonymous SNP (Gly671Val) located in the exon 16 at the nucleotide binding domain of the protein [13]. Login to comment