PMID: 18824712

Raymond E, Brandes AA, Dittrich C, Fumoleau P, Coudert B, Clement PM, Frenay M, Rampling R, Stupp R, Kros JM, Heinrich MC, Gorlia T, Lacombe D, van den Bent MJ
Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study.
J Clin Oncol. 2008 Oct 1;26(28):4659-65., 2008-10-01 [PubMed]
Sentences
No. Mutations Sentence Comment
61 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 18824712:61:82
status: VERIFIED
view ABCG2 p.Gln141Lys details
 Raymond et al 4660 17) as previously described.17 Genotyping for the hypomorphic Q141K ABCG2 polymorphism was performed using tumor DNA and a Fluorescent Resonance Energy Transfer-based hybridization probes and melting curve analysis using a Roche LC480 instrument (Roche, Neuilly sur Seine, France; primer, probe, and polymerase chain reaction conditions available on request).18 Statistical Analysis Demographic, response rate, safety, laboratory, PK, and pharmacodynamic data were analyzed using descriptive statistics. Login to comment 100 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 18824712:100:24
status: VERIFIED
view ABCG2 p.Gln141Lys details
 Twelve patients had the Q141K exon 5 SNP. Login to comment