PMID: 18624680

Murakami T, Takano M
Intestinal efflux transporters and drug absorption.
Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):923-39., [PubMed]
Sentences
No. Mutations Sentence Comment
183 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 18624680:183:63
status: NEW
view ABCG2 p.Gln141Lys details
ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 18624680:183:64
status: NEW
view ABCG2 p.Gln141Lys details
 A common single polymorphism (SNP) in• ABCG2 (421C > A; Q141K) in two patients showed a 1.34-fold increased oral bioavailability of irinotecan (topotecan) compared to the bioavailability in ten patients with the wild type allele (42.0% versus 31.4%; p = 0.037) [77]. Login to comment