ABCMdb

PMID: 18423665

Hegedus T, Serohijos AW, Dokholyan NV, He L, Riordan JR
Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR.
J Mol Biol. 2008 May 16;378(5):1052-63. Epub 2008 Mar 26., [PubMed]

Sentences

No. Mutations Sentence Comment

27 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala Replacement of serine with alanine at position 737 or 768 was reported to produce a channel with a higher level of activity in both the non-phosphorylated and phosphorylated state.16,19-21 These studies led to the indirect conclusion that these two sites are inhibitory in their phosphorylated state. Login to comment 28 ABCC7 p.Ser737Ala ABCC7 p.Ser768Ala Replacement of serine with alanine at position 737 or 768 was reported to produce a channel with a higher level of activity in both the non-phosphorylated and phosphorylated state.16,19-21 These studies led to the indirect conclusion that these two sites are inhibitory in their phosphorylated state. Login to comment