PMID: 18408567

Urquhart BL, Ware JA, Tirona RG, Ho RH, Leake BF, Schwarz UI, Zaher H, Palandra J, Gregor JC, Dresser GK, Kim RB
Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe.
Pharmacogenet Genomics. 2008 May;18(5):439-48., [PubMed]
Sentences
No. Mutations Sentence Comment
21 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 18408567:21:175
status: VERIFIED
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ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 18408567:21:137
status: VERIFIED
view ABCG2 p.Val12Met details
 In addition, several nonsynonymous single nucleotide polymorphisms (SNPs) of the ABCG2 gene have been described including ABCG2 34G > A (V12M) located in exon 2 and 421C > A (Q141K) in exon 5. Login to comment 62 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 18408567:62:114
status: VERIFIED
view ABCG2 p.Gln141Lys details
ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 18408567:62:94
status: VERIFIED
view ABCG2 p.Val12Met details
 Site-directed mutagenesis was utilized to create the nonsynonymous allelic variants, 34G > A (V12M) and 421C > A (Q141K). Login to comment