PMID: 18079276

Zhou L, Naraharisetti SB, Wang H, Unadkat JD, Hebert MF, Mao Q
The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study.
Mol Pharmacol. 2008 Mar;73(3):949-59. Epub 2007 Dec 13., [PubMed]
Sentences
No. Mutations Sentence Comment
323 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 18079276:323:77
status: VERIFIED
view ABCG2 p.Gln141Lys details
 For example, the fetuses of pregnant women carrying the BCRP natural variant Q141K, which displays lower transport activity (Imai et al., 2002), may be at increased risk for the GLB toxicity. Login to comment