ABCMdb

PMID: 18068529

Maruta Y, Okayama N, Hiura M, Suehiro Y, Hirai H, Hinoda Y
Determination of ancestral allele for possible human cancer-associated polymorphisms.
Cancer Genet Cytogenet. 2008 Jan 1;180(1):24-9., 2008-01-01 [PubMed]

Sentences

No. Mutations Sentence Comment

0 ABCG2 p.Gln141Lys Determination of ancestral allele for possible human cancer-associated polymorphisms Yuichi Marutaa,b , Naoko Okayamab , Mikako Hiuraa , Yutaka Suehiroa , Hirohisa Hiraic , Yuji Hinodaa,b,* a Department of Laboratory Medicine, Yamaguchi University Graduate School of Medicine, 1-1-1, Minami-Kogushi, Ube, Yamaguchi 755-8505 Japan b Division of Clinical Laboratory, Yamaguchi University Hospital, Ube, Japan c Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Japan Received 31 August 2007; accepted 19 September 2007 Abstract To determine ancestral allele in possible cancer-associated polymorphisms, DNA samples from 10 chimpanzees (Pan troglodytes) were sequenced for alleles corresponding to 17 polymorphisms: 8 short tandem repeats [IL1RN (alias IL-1RA) variable number tandem repeat (VNTR); TYMS (previously TS ) VNTR; AR CAG repeat; dinucleotide repeats of UGT1A1, IGF1, IFNG (alias IFN-g), ESR1 (alias ER-a), and EGFR] and 9 single nucleotide polymorphisms (MMP1-1607 1G/2G, MMP3-1171 5A/6A, OGG1 Ser326Cys, ALDH2 Gly487Lys, TP53 Arg72Pro, ABCG2 Gln141Lys, MGMT Leu84Phe, SOD2 Ala-9Val, and MTHFR Ala222Val). Login to comment 42 ABCG2 p.Gln141Lys subfamily G2 ABCG2 Gln141Lys (rs2231142); O-6-methylguanine-DNA methyltransferase MGMT Leu84Phe (rs12917); mitochondrial superoxide dismutase SOD2 (alias MnSOD) Ala-9Val (rs4880); and methylenetetrahydrofolate reductase MTHFR Ala222Val (rs1801133). Login to comment