ABCMdb

PMID: 18025408

Rafiq M, Flanagan SE, Patch AM, Shields BM, Ellard S, Hattersley AT
Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations.
Diabetes Care. 2008 Feb;31(2):204-9. Epub 2007 Nov 19., [PubMed]

Sentences

No. Mutations Sentence Comment

54 ABCC8 p.Val86Ala ABCC8 p.Phe132Leu ABCC8 p.Asp212Ile ABCC8 p.Asp209Glu ABCC8 p.Thr229Ile ABCC8 p.Thr229Ile ABCC8 p.Glu208Lys ABCC8 p.Pro45Leu ABCC8 p.Val607Met ABCC8 p.Asp209Asn ABCC8 p.Val215Ile Doses Table 1-Clinical characteristics of patients with SUR1 mutations according to success of treatment with sulfonylureas Characteristic All patients Patients with successful sulfonylurea treatment Patients with unsuccessful sulfonylurea treatment P* n 27 23 4 Mutation (number of patients) NA V86G†, P45L/G1401R- (2)†, D209E (3)†, T229I/V1523L†, Q211K†, V86A (2)†, E1507G, V215I/V607M, E208K/Y263D†, R1380L (2)‡, D212I (3)§, T229I/T229I‡, R1183W§, L225P†, R826W, and D209N F132L (2)†, F132V†, and N72S† (mosaic). Login to comment 56 ABCC8 p.Val86Ala ABCC8 p.Phe132Leu ABCC8 p.Asp212Ile ABCC8 p.Asp209Glu ABCC8 p.Thr229Ile ABCC8 p.Thr229Ile ABCC8 p.Glu208Lys ABCC8 p.Pro45Leu ABCC8 p.Val607Met ABCC8 p.Asp209Asn ABCC8 p.Val215Ile Doses Table 1-Clinical characteristics of patients with SUR1 mutations according to success of treatment with sulfonylureas Characteristic All patients Patients with successful sulfonylurea treatment Patients with unsuccessful sulfonylurea treatment P* n 27 23 4 Mutation (number of patients) NA V86Gߤ, P45L/G1401R- (2)ߤ, D209E (3)ߤ, T229I/V1523Lߤ, Q211Kߤ, V86A (2)ߤ, E1507G, V215I/V607M, E208K/Y263Dߤ, R1380L (2)ߥ, D212I (3)&#a7;, T229I/T229Iߥ, R1183W&#a7;, L225Pߤ, R826W, and D209N F132L (2)ߤ, F132Vߤ, and N72Sߤ (mosaic). Login to comment 75 ABCC8 p.Phe132Leu ABCC8 p.Phe132Val Two of these patients with F132V and F132L mutations had increased C-peptide levels following the transfer, but it was decided that the response was insufficient to discontinue insulin. Login to comment 77 ABCC8 p.Phe132Leu ABCC8 p.Phe132Val Two of these patients with F132V and F132L mutations had increased C-peptide levels following the transfer, but it was decided that the response was insufficient to discontinue insulin. Login to comment