PMID: 17938643

Erdilyi DJ, Kamory E, Csokay B, Andrikovics H, Tordai A, Kiss C, Filni-Semsei A, Janszky I, Zalka A, Fekete G, Falus A, Kovacs GT, Szalai C
Synergistic interaction of ABCB1 and ABCG2 polymorphisms predicts the prevalence of toxic encephalopathy during anticancer chemotherapy.
Pharmacogenomics J. 2008 Oct;8(5):321-7., [PubMed]
Sentences
No. Mutations Sentence Comment
23 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 17938643:23:451
status: VERIFIED
view ABCG2 p.Gln141Lys details
ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 17938643:23:442
status: VERIFIED
view ABCG2 p.Val12Met details
 According to the first theory this SNP and other variations (2677G4T/A and 1236C4T) in linkage disequilibrium are linked to a putative functional polymorphism that causes the differences observed.10 On the other hand it was shown that the 3435T mRNA is characterized by decreased stability, while the linked alleles themselves have no effect on gene expression.11 The ABCG2 34G4A and 421C4A are rare non-synonymous polymorphisms resulting in V12M and Q141K variations. Login to comment