PMID: 17627617

Jada SR, Lim R, Wong CI, Shu X, Lee SC, Zhou Q, Goh BC, Chowbay B
Role of UGT1A1*6, UGT1A1*28 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients.
Cancer Sci. 2007 Sep;98(9):1461-7. Epub 2007 Jul 11., [PubMed]
Sentences
No. Mutations Sentence Comment
21 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 17627617:21:179
status: VERIFIED
view ABCG2 p.Gln141Lys details
 Apart from the influence of UGT1A1*6 and UGT1A1*28 on irinotecan-induced neutropenia, a recent in vitro study by Imai et al.(16) suggested that the non-synonymous ABCG2 c.421C>A (Q141K) polymorphism in exon 5 exhibited low-level drug resistance and increased the sensitivity of normal cells to SN-38 compared with cell lines transfected with ABCG2 gene harboring the reference genotype. Login to comment