PMID: 17581627

Kramer U, Illig T, Grune T, Krutmann J, Esser C
Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype.
Genes Immun. 2007 Sep;8(6):513-7. Epub 2007 Jun 21., [PubMed]
Sentences
No. Mutations Sentence Comment
71 ABCB3 p.Arg651Cys
X
ABCB3 p.Arg651Cys 17581627:71:703
status: NEW
view ABCB3 p.Arg651Cys details
ABCB3 p.Thr665Ala
X
ABCB3 p.Thr665Ala 17581627:71:795
status: NEW
view ABCB3 p.Thr665Ala details
 Owing to a recombination hot spot, a second independent Table 1 Genotype frequencies in cases and controls of psoriasis patients2 ordered by frequency Locus/effect Genotype Genotype frequencies Odds ratio (95% confidence limits) w2 P-value P-value after Bonferroni correction (six independent tests) Cases Control LMP2_60/Arg60His G/G 0.64 0.52 2.50 (1.41-4.45) 9.73 0.0018 0.0108 A/G 0.33 0.41 A/A 0.04 0.07 TAP1_637/Asp637Gly A/A 0.71 0.79 2.50 (1.25-5.02) 6.64 0.0100 0.0600 A/G 0.26 0.19 G/G 0.03 0.02 LMP7_49/Lys49Gln C/C 0.66 0.74 1.93 (0.98-3.80) 3.66 0.0556 0.3336 A/C 0.31 0.24 A/A 0.03 0.02 TAP2_565/Thr565Ala C/C 0.88 0.86 1.25 (0.52-2.99) 0.24 0.6215 - C/T 0.12 0.13 T/T 0.01 0.01 TAP2_651/Arg651Cys C/C 0.89 0.87 1.40 (0.50-3.90) 0.40 0.5621 - C/T 0.11 0.13 T/T 0.00 0.00 TAP2_665/Thr665Ala A/A 0.37 0.53 3.18 (1.84-5.48) 17.23 0.00002 0.00012 A/G 0.49 0.41 G/G 0.14 0.06 TAP2_687/À687Gln T/T 0.37 0.53 3.27 (1.90-5.63) 18-27 0.00002 0.00012 C/T 0.49 0.41 C/C 0.14 0.06 Genotyping analyses were carried out by using the MassARRAY system (Sequenom, San Diego, CA, USA). Login to comment