ABCMdb

PMID: 17543849

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamaki J, Mykkanen H, Agren JJ, Rauramaa R, Laakso M, Miettinen TA
Cholesterol synthesis prevails over absorption in metabolic syndrome.
Transl Res. 2007 Jun;149(6):310-6. Epub 2007 May 23., [PubMed]

Sentences

No. Mutations Sentence Comment

22 ABCG8 p.Asp19His In addition, weight reduction in type 2 diabetes increases the fractional absorption of cholesterol.8 Regarding the genetic regulation, the D19H polymorphism of the ABCG8 gene is more frequent in subjects with low than high absorption of cholesterol.10 These results suggest that cholesterol metabolism is interrelated to body weight and insulin action, and one possible regulatory pathway might be through the adenosine triphosphate cassette transporter system. Login to comment 23 ABCG8 p.Asp19His In addition, weight reduction in type 2 diabetes increases the fractional absorption of cholesterol.8 Regarding the genetic regulation, the D19H polymorphism of the ABCG8 gene is more frequent in subjects with low than high absorption of cholesterol.10 These results suggest that cholesterol metabolism is interrelated to body weight and insulin action, and one possible regulatory pathway might be through the adenosine triphosphate cassette transporter system. Login to comment 110 ABCG5 p.Gln604Glu ABCG8 p.Asp19His ABCG8 p.Thr400Lys Polymorphisms of the different genes tested were evenly distributed between MBO and controls (heterozygotesaf9;homozygotes/wild type: ABCG8: D19H, MBO 16/56, controls 13/61; T400K, MBO 29/ 43, controls 26/48; A632V, MBO 27/45, controls 27/ 47; ABCG5: Q604E, MBO 16/56, controls 16/58). Login to comment 111 ABCG5 p.Gln604Glu ABCG8 p.Asp19His ABCG8 p.Thr400Lys Polymorphisms of the different genes tested were evenly distributed between MBO and controls (heterozygotesϩhomozygotes/wild type: ABCG8: D19H, MBO 16/56, controls 13/61; T400K, MBO 29/ 43, controls 26/48; A632V, MBO 27/45, controls 27/ 47; ABCG5: Q604E, MBO 16/56, controls 16/58). Login to comment 143 ABCG8 p.Asp19His It has been shown earlier that the genetic polymorphisms of ABCG510 and ABCG810,20 were associated with variables of cholesterol metabolism, and the D19H polymorphism of the ABCG8 gene was overrepresented in subjects with low cholesterol absorption.10 In this study, the distribution of the common polymorphisms of these genes did not differ between MBO and controls. Login to comment 144 ABCG8 p.Asp19His It has been shown earlier that the genetic polymorphisms of ABCG510 and ABCG810,20 were associated with variables of cholesterol metabolism, and the D19H polymorphism of the ABCG8 gene was overrepresented in subjects with low cholesterol absorption.10 In this study, the distribution of the common polymorphisms of these genes did not differ between MBO and controls. Login to comment