PMID: 17481587

Bram EE, Ifergan I, Grimberg M, Lemke K, Skladanowski A, Assaraf YG
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
Biochem Pharmacol. 2007 Jun 30;74(1):41-53. Epub 2007 Apr 1., 2007-06-30 [PubMed]
Sentences
No. Mutations Sentence Comment
110 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 17481587:110:37
status: NEW
view ABCG2 p.Gln141Lys details
 C-1311 accumulation in HEK293 ABCG2 (Q141K) transfectant cells was carried out as above with the exceptions of using a C-1311 concentration range of 0.1-10 mM and the use of the alternative ABCG2 efflux inhibitor fumitremorgin C (5 mM) when co-incubated with C-1311. Login to comment 290 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 17481587:290:144
status: NEW
view ABCG2 p.Gln141Lys details
 [17] Imai Y, Nakane M, Kage K, et al. C421 polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low level drug resistance. Login to comment