PMID: 17354009

Macdonald N, Gledhill A
Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans.
Arch Toxicol. 2007 Aug;81(8):553-63. Epub 2007 Mar 13., [PubMed]
Sentences
No. Mutations Sentence Comment
132 ABCB1 p.Met986Val
X
ABCB1 p.Met986Val 17354009:132:230
status: NEW
view ABCB1 p.Met986Val details
ABCC2 p.Leu849Met
X
ABCC2 p.Leu849Met 17354009:132:129
status: NEW
view ABCC2 p.Leu849Met details
 Only two known human SNP results in change of an amino acid in a transmembrane domain, A2547G which results in substitution of a methionine in place of leucine 849 (Kroetz et al. 2003), and A2956G which results in substitution of valine in place of methionine at amino acid 986 (Tanabe et al. 2001). Login to comment